Results 161 to 170 of about 20,969 (214)
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SEX HORMONE BINDING GLOBULIN IN SALIVA
Clinical Endocrinology, 1988SUMMARYMeasurement of salivary steroid hormone concentrations has frequently been advocated as a convenient alternative to plasma measurements. This is partly due to the belief that salivary steroid concentrations are a reliable reflection of the plasma free hormone level, a belief reinforced by earlier inability to demonstrate the presence of ...
C, Selby, P A, Lobb, W J, Jeffcoate
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Sex hormone-binding globulin in osteoporosis
Joint Bone Spine, 2010Sex hormone-binding globulin (SHBG) is a plasma glycoprotein that binds with high affinity to sex steroids, most notably 5alpha-dihydrotestosterone, testosterone, and 17beta-estradiol, thereby regulating their bioavailability and access to target cells. SHBG modulates the sex-steroid signaling system by binding to a specific membrane receptor (SHBG-R).
Hoppé, Emmanuel +4 more
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Trends in Endocrinology and Metabolism, 2021
Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study has provided new insights at the population level.
Simons, Pomme I. H. G. +3 more
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Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study has provided new insights at the population level.
Simons, Pomme I. H. G. +3 more
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Plasma Variation of Corticosteroid-binding Globulin and Sex Hormone-binding Globulin
Hormone and Metabolic Research, 2006Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) circulate in plasma and bind their cognate ligands with high affinity, offering a steroid delivery system to target tissues by a variety of mechanisms. Analysis of these steroid-binding proteins is gaining importance in the clinical setting, although more information is ...
J G, Lewis +6 more
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Sex-Hormone-Binding Globulin is an Oestrogen Amplifier
Nature, 1972WE suggest a novel biological role for a specific plasma-binding protein in the regulation of oestrogen and androgen activity in man. The biological activity of oestradiol and testosterone, as with other steroids1, is probably exerted by the unbound fraction in plasma; this is only 1–3% of the total concentration.
C W, Burke, D C, Anderson
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Effects of oestradiol on sex hormone binding globulin
Acta Endocrinologica, 1982Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol ...
V, Odlind +4 more
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Clinical Endocrinology, 1974
A review was made to understand how plasma binding protein might influence sex-hormone action in target tissues. Steroids are predominately bound to plasma proteins and only unbound steroids enter the cells. Sex-hormone-binding globulin (SHBG) binds to both the main circulating steroid T and E2 but changes in SHBG concentrations exert significant ...
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A review was made to understand how plasma binding protein might influence sex-hormone action in target tissues. Steroids are predominately bound to plasma proteins and only unbound steroids enter the cells. Sex-hormone-binding globulin (SHBG) binds to both the main circulating steroid T and E2 but changes in SHBG concentrations exert significant ...
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Sex Hormone Binding Globulin in Clinical Perspective
Acta Obstetricia et Gynecologica Scandinavica, 1987The plasma steroid‐binding proteins play a fundamental role in the modification and delivery of the steroid “signal” to its target tissue. While their precise function requires further evaluation, the measurement of these proteins, particularly of SHBG, provides clinically useful information.This article reviews the current theories of sex steroid ...
A, Bond, C, Davis
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Sex Hormone Binding Globulin in Carcinoma of the Prostate
British Journal of Urology, 1977Sex Hormone Binding Globulin (SHBG) was measured in 130 patients with carcinoma of the prostate. Its level is raised in patients treated with oestrogen and it is possible that this may be of prognostic significance. The possible relevance of SHBG in oestrogen-treated patients is discussed.
A L, Houghton, R, Turner, E H, Cooper
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Dexamethasone suppresses sex-hormone binding globulin
Fertility and Sterility, 1988Dexamethasone suppression (DEX-S) for 14 days has been used to determine the probable source of androgen excess. The exact mechanism(s) of DEX-S is still unclear. The authors postulated that dexamethasone (DEX) inhibits either the synthesis or secretion of sex-hormone binding globulin (SHBG). To examine this hypothesis, 14 women with polycystic ovarian
R E, Blake +3 more
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