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Sex hormone-binding globulin in gestational diabetes
Acta Obstetricia et Gynecologica Scandinavica, 2000Insulin is an important regulator of serum sex hormone-binding globulin (SHBG) concentration which works by inhibiting its production in hepatocytes. Low SHBG level is associated with increased insulin resistance and hyperinsulinemia. Our purpose was to compare maternal serum SHBG level between normal and gestational diabetic pregnant women and to ...
J L, Bartha +3 more
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Hormonal contraceptives and plasma sex hormone binding globulin
Contraception, 1975Human blood plasma contains beta-globulin (molecular weight about 100000) which shows high binding affinity for both estradiol 17-beta and testosterone. It is called the sex hormone binding globulin (SHBG). There is a 4-8 fold increase during pregnancy a 2-3 fold increase with administration of synthetic estrogens but progestogens may induce a ...
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Sex hormone binding globulin in breast cancer
La Ricerca in Clinica e in Laboratorio, 1980Using a binding assay for sex hormone binding globulin, a Japanese group showed that they could select breast cancer patients more likely to be responsive to endocrine therapy, i.e. oestrogen receptor positive patients, by an increase in oestrogen binding capacity of the protein.
M, Bowen +3 more
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European Journal of Applied Physiology and Occupational Physiology, 1996
The response of total testosterone (T), free testosterone (fT), sex hormone-binding globulin (SHBG) and non-SHBG-bound testosterone (NST) to the same exercise protocol was evaluated in two different experiments on long distance runners. The first experiment was performed in the morning at 0900 hours with nine athletes, while the second was carried out ...
Bonifazi M., Lupo C.
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The response of total testosterone (T), free testosterone (fT), sex hormone-binding globulin (SHBG) and non-SHBG-bound testosterone (NST) to the same exercise protocol was evaluated in two different experiments on long distance runners. The first experiment was performed in the morning at 0900 hours with nine athletes, while the second was carried out ...
Bonifazi M., Lupo C.
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Nonlinear binding of sex steroids to albumin and sex hormone binding globulin
European Journal of Drug Metabolism and Pharmacokinetics, 1997We have studied the binding of sex steroids to albumin and sex hormone binding globulin (SHBG) using gel filtration chromatography for the separation of the bound from the free fraction of the steroid. It was found that estradiol binds to the globulin and albumin in a nonlinear manner: a lag period of binding was observed at low concentrations of the ...
T, Zeginiadou +3 more
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Sex hormone-binding globulin and thyroxine-binding globulin levels in premature thelarche
Steroids, 1988Premature thelarche is defined as the isolated development of breast tissue in girls less than 8 years of age. Although breast development is an estrogen-dependent process, these girls do not have elevated serum estrogen levels, and the hormonal basis for their condition is unclear.
G B, Wenick, F I, Chasalow, S L, Blethen
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Free estradiol and sex hormone-binding globulin
Steroids, 2015SHBG is a plasma protein that participates in the regulation of free estradiol and free testosterone in plasma. We discuss the concept of the nature of a free estradiol and how best to ascertain its value. It can be measured or calculated; the ways in which this can be done are explored along with the advantages and disadvantages of each.
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Sex hormone‐binding globulin as a marker for the thrombotic risk of hormonal contraceptives
Journal of Thrombosis and Haemostasis, 2012It takes many years to obtain reliable values for the risk of venous thrombosis of hormonal contraceptive users from clinical data. Measurement of activated protein C (APC) resistance via thrombin generation is a validated test for determining the thrombogenicity of hormonal contraceptives.
Raps, M. +7 more
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Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Obesity in Men and Women
Hormone and Metabolic Research, 2000Sex steroid hormones in both males and females have been closely related to the regulation of adiposity, either through direct or indirect physiological mechanisms. Evidence also suggests a direct relationship between sex hormones and risk factors for cardiovascular disease.
A, Tchernof, J P, Després
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SEX HORMONE BINDING GLOBULIN IN WOMEN WITH ANOREXIA NERVOSA
Clinical Endocrinology, 1986SUMMARYIn 29 women with anorexia nervosa, on a blood sample withdrawn at 0900 h before and during weight gain, the binding parameters of serum sex hormone binding globulin (SHBG) were measured by a solid phase method and the levels of testosterone, oestradiol and thyroid hormones were measured by radioimmunoassay.
B, Estour +5 more
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