Results 31 to 40 of about 5,913,081 (214)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Sex, Aggression, and Pain: Sociobiological Implicatios for Theological Anthropology
Zygon, 1998 Theological anthropology can be enriched by paying attention to insights into human behavior taken from sociobiology. The capacity for reflective self‐consciousness enables the human animal to respond to basic instincts and drives in unprecedented ways.
doaj +2 more sources
Frontiers in Neuroscience, 2023 IntroductionAdverse early life experiences affect neuronal growth and maturation of reward circuits that modify behavior under reward predicting conditions.
Ermis Ryakiotakis +3 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Sexual behavior and testis morphology in the BACHD rat model. [PDF]
PLoS ONE, 2018 BACKGROUND:Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, which results in brain neurodegeneration and peripheral pathology affecting different organs including testis ...
Arianna Novati +4 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The impact of COVID-19 on sexual health: a preliminary framework based on a qualitative study with clinical sexologists [PDF]
, 2020 Introduction: In recent months, some attempts were made to understand the impact of COVID-19 on sexual health. Despite recent research that suggests COVID-19 and lockdown measures may eventually impact sexual response and sexually related behaviors, we ...
Ana Filipa Beato +12 more
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Animal models for bipolar disorder: from bedside to the cage
International Journal of Bipolar Disorders, 2017 Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior ...
Dominik K. E. Beyer, Nadja Freund
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Evolutionary pets: offspring numbers reveal speciation process in domesticated chickens. [PDF]
PLoS ONE, 2012 Since Darwin, the nature of the relationship between evolution and domestication has been debated. Evolution offers different mechanisms of selection that lead to adaptation and may end in the origin of new species as defined by the biological species ...
Inga Tiemann, Gerd Rehkämper
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source