Results 71 to 80 of about 323,029 (308)

A New Female Rat Animal Model for Hypoactive Sexual Desire Disorder; Behavioral and Pharmacological Evidence

The Journal of Sexual Medicine, 2011
ABSTRACTIntroductionFemale sexual dysfunction (FSD) affects 33–48% of women. Female rats with low sexual activity might model FSD.AimIn this study, we have investigated whether in a population of normal female rats, subpopulations of rats exist with different levels of sexual behavior.MethodsSexually experienced, intact, estradiol-primed female rats ...
Snoeren, E.M.S., Chan, J.S.W., de Jong, T.R., Waldinger, M.D., Olivier, B., Oosting, R.S.   +5 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mpox Epidemiology and Risk Factors, Nigeria, 2022

Emerging Infectious Diseases
To investigate epidemiology of and risk factors for laboratory-confirmed mpox during the 2022 outbreak in Nigeria, we enrolled 265 persons with suspected mpox. A total of 163 (61.5%) were confirmed to have mpox; 137 (84.0%) were adults, 112 (68.7%) male,
Dimie Ogoina, Mahmmod Muazu Dalhat, Ballah Akawu Denue, Mildred Okowa, Nneka Marian Chika-Igwenyi, Sebastine Oseghae Oiwoh, Ekaete Alice Tobin, Hakeem Abiola Yusuff, Anastacia Okwudili Ojimba, Umenzekwe Chukwudi Christian, John-Tunde Aremu, Simji Samuel Gomerep, Kambai Lalus Habila, Sati Klein Awang, Olukemi Adekanmbi, Michael Iroezindu, Asukwo Onukak, Olanrewaju Falodun, Mogaji Sunday, Simon Mafuka Johnson, Abimbola Olaitan, Chizaram Onyeaghala, Datonye Alasia, Juliet Mmerem, Uche Unigwe, Vivian Kwaghe, Mukhtar Abdulmajid Adeiza   +26 more
doaj   +1 more source

Multiple Signaling Functions Of Song In A Polymorphic Species With Alternative Reproductive Strategies [PDF]

, 2017
Vocal traits can be sexually selected to reflect male quality, but may also evolve to serve additional signaling functions. We used a long-term dataset to examine the signaling potential of song in dimorphic white-throated sparrows (Zonotrichia ...
Formica, Vincent A., Gonser, R. A., Grunst, A. S., Grunst, M. L., Tuttle, E. M.   +4 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice

Asian Journal of Andrology, 2016
Twenty-four-month-old male C57BL/6 mice with low serum testosterone levels were used as a late-onset hypogonadism (LOH) animal model for examining the effects of velvet antler polypeptide (VAP) on sexual function and testosterone synthesis.
Zhi-Jun Zang, Hong-Feng Tang, Ying Tuo, Wei-Jie Xing, Su-Yun Ji, Yong Gao, Chun-Hua Deng   +6 more
doaj   +1 more source

Multimodal characterization of Yucatan minipig behavior and physiology through maturation

Scientific Reports, 2021
Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the ...
Alesa H. Netzley, Ryan D. Hunt, Josue Franco-Arellano, Nicole Arnold, Ana I. Vazquez, Kirk A. Munoz, Aimee C. Colbath, Tamara Reid Bush, Galit Pelled   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Sexually Dimorphic Effect of Environmental Enrichment and Weaning on Stress in Piglets

Animals
Most intensive swine production systems use invasive practices that increase stress and compromise animal welfare. Apparently, the way in which animals respond to stress is sexually dimorphic.
Guadalupe Espejo-Beristain, Pedro Paredes-Ramos, Concepción Ahuja-Aguirre, Apolo Carrasco-García   +3 more
doaj   +1 more source