Results 61 to 70 of about 74,218 (307)

Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics

Heliyon
Stress is a complex and multifaceted phenomenon that can significantly influence both aggressive behavior and sexual function. This review explores the intricate relationship between stress, neuromodulator pathways, and epigenetics, shedding light on the
Ngala Elvis Mbiydzenyuy, Sian Megan Joanna Hemmings, Thando W. Shabangu, Lihle Qulu-Appiah   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An overview of the current methodologies used for evaluation of aphrodisiac agents

Journal of Acute Disease, 2013
Discoveries in the past two decades have continued to improve our understanding of the pathophysiology of erectile dysfunction disease and animal models have played a significant role to define the basic mechanisms of erectile dysfunction treatment. Both
Ramandeep Singh, Ashraf Ali, G. Jeyabalan, Alok Semwal, Jaikishan   +4 more
doaj   +1 more source

Developing a Catalog of Socio-Sexual Behaviors of Beluga Whales (Delphinapterus leucas) in the Care of Humans [PDF]

, 2015
The repertoire of socio-sexual and sexual behaviors of cetaceans is relatively unknown. The purpose of the current study was to advance the existing knowledge of socio-sexual behavior of beluga whales through the development of a behavioral catalog that ...
Sarah Dietrich, Dietrich, Sarah, Heather M. Hill, Malin Miller, Aibel, Steve, Deirdre Yeater, Al Dove, McKinnon, Mariyah, Yeater, Deirdre, Hill, Heather M., Heather Hill, Steve Aibel, Miller, Malin, Dove, Al, Mariyah McKinnon   +14 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Mpox Epidemiology and Risk Factors, Nigeria, 2022

Emerging Infectious Diseases
To investigate epidemiology of and risk factors for laboratory-confirmed mpox during the 2022 outbreak in Nigeria, we enrolled 265 persons with suspected mpox. A total of 163 (61.5%) were confirmed to have mpox; 137 (84.0%) were adults, 112 (68.7%) male,
Dimie Ogoina, Mahmmod Muazu Dalhat, Ballah Akawu Denue, Mildred Okowa, Nneka Marian Chika-Igwenyi, Sebastine Oseghae Oiwoh, Ekaete Alice Tobin, Hakeem Abiola Yusuff, Anastacia Okwudili Ojimba, Umenzekwe Chukwudi Christian, John-Tunde Aremu, Simji Samuel Gomerep, Kambai Lalus Habila, Sati Klein Awang, Olukemi Adekanmbi, Michael Iroezindu, Asukwo Onukak, Olanrewaju Falodun, Mogaji Sunday, Simon Mafuka Johnson, Abimbola Olaitan, Chizaram Onyeaghala, Datonye Alasia, Juliet Mmerem, Uche Unigwe, Vivian Kwaghe, Mukhtar Abdulmajid Adeiza   +26 more
doaj   +1 more source

Children and animal abuse: Criminological, victimological and criminal justice aspects [PDF]

Temida, 2011
Animal abuse represents a complex social, psychological, criminological, victimological and legal phenomenon whose gravity is increased if a child appears either as the perpetrator or as the observer of violence against animals.
Batrićević Ana
doaj   +1 more source

Chronic Maternal Tobacco Smoke Exposure and/or Alpha-Lipoic Acid Treatment Causes Long-Term Deterioration of Testis and Sexual Behavior in Adult Male Rats

, 2020
Background: Tobacco use during pregnancy is known to have several negative effects on the offspring's reproductive health in the long term. The use of alpha-lipoic acid (ALA) as a dietary supplement during pregnancy has increased greatly in recent years ...
Yardimc, Ahmet, Ramazan Fazil Akkoc, Ahmet Tektemur, Nazife Ulker, Nalan Kaya Tektemur, Elif Erdem Güzel, Sinan Canpolat, Ibrahim Enver Ozan, Erdem Güzel, Elif   +2 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source