Results 81 to 90 of about 1,886,097 (301)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Cybersex activity, self-control, and premarital sexual behaviors among adolescents

Healthcare in Low-resource Settings
Rapidly growing internet use among adolescents had positive and negative effects. It offers benefits, such as facilitating communication, but it also has negative impacts, including premarital sexual behaviors. The purpose of this study was to determine
Puji Hastuti, Adellia Eka Kartikasari, Taufan Agung Prasetya, Astrida Budiarti   +3 more
doaj   +1 more source

Sexual satisfaction among young women: the frequency of sexual activities as a mediator

Anales de Psicologia, 2017
The aim of this study is to analyze the relationship among several social-cognitive predictors of sexual behavior (beliefs, knowledge, attitudes and values), sexual behaviors, the frequency of sexual activities and different dimensions of sexual ...
Adelaida I. Ogallar Blanco, Débora Godoy Izquierdo, Mª Luisa Vázquez Pérez, Juan F. Godoy   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

I Did What Last Night? Adolescent Risky Sexual Behaviors and Substance Abuse [PDF]

Risky sexual behaviors by teenagers have shown to be strongly correlated with drug and alcohol consumption. The purpose of this study is to examine the question of whether alcohol and drug use increases the likelihood that teenagers will engage in four ...
Michael Grossman, Sarah Markowitz
core  

638 May social media be a tool in promoting sexual health? Youth’s use, professional’s attitudes and current sexual education programs

, 2018
Objectives: Social Media (SM) and on-line communities have become important communication channels for young people. The massive use of these technologies by new generations gave rise to an international debate regarding the potential effects on ...
Nimbi, F. M., Todaro, E., Silvaggi, M., Tripodi, F., Rossi, R., Aversa, F., Rossi, V., Simonelli, C.   +7 more
core   +1 more source

A cross-sectional path analysis of the social determinants of STI preventive behaviors: application of the WHO framework

Scientific Reports
Sexually transmitted infections (STIs) remain a major public health concern. Preventive behaviors can reduce their burden, and social determinants of health may influence these behaviors.
Fatemeh Vakili, Masoumeh Masoumi, Fariba Valiey, Fatemeh Asadi, Malihe Nasiri, Shayesteh Jahanfar, Zeinab Hamzehgardeshi, Seideh Hanieh Alamolhoda   +7 more
doaj   +1 more source

Sexual desire for non-normative sexual behaviors: differences between centennials and millennials considering sexual orientation

Frontiers in Sociology
IntroductionNon-normative sexual behaviors were traditionally studied from a psychopathological perspective, although nowadays a distinction is made between paraphilia (nonpathological) and paraphilic disorder (mental disorder).MethodsThe present study ...
Alberto Paramio, Alberto Paramio, Ricardo Tejeiro, Antonio Romero-Moreno, Antonio Romero-Moreno, María Rusillo-Molina, Serafín Cruces-Montes, Serafín Cruces-Montes   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source