Role of Gonadal Steroid Hormones in the Eye: Therapeutic Implications [PDF]
BiomoleculesGonadal steroid hormones are critical regulatory substances involved in various developmental and physiological processes from fetal development through adulthood. These hormones, derived from cholesterol, are synthesized primarily by the gonads, adrenal
Javier Valero-Ochando +2 more
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Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones [PDF]
Biology of Sex Differences, 2021 Background As in other types of cancers, sex is an essential factor in the origin and progression of glioblastomas. Research in the field of endocrinology and cancer suggests that gonadal steroid hormones play an important role in the progression and ...
Ignacio Camacho-Arroyo +1 more
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Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease [PDF]
Frontiers in Molecular Neuroscience, 2018 Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are modulated by local metabolism of the hormones within the brain. Such control is necessary to maintain normal function, as several signaling pathways that are activated by ...
Neil J Maclusky
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Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth [PDF]
Maternal-Fetal Medicine, 2023 . In 2019, preterm births (PTB) accounted for approximately 0.66 million deaths globally. PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns.
Yang Pan +8 more
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Temporal organization of gonadal and adrenal steroid fluctuations in male mice [PDF]
Endocrine ConnectionsLongitudinal arterial sampling combined with LC–MS/MS profiling was used to define the temporal organization of circulating steroid hormones in adult male mice.
M Chase Kettering +8 more
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Transcriptomic and metabolomic analysis of metabolite changes and regulatory mechanisms associated with gonadal degeneration in yellow oil crab (Scylla paramamosain) [PDF]
BMC GenomicsBackground The yellow oil crab is a highly valuable aquatic species, with the accumulation of nutritional and flavor compounds closely linked to the degree of gonadal degeneration. However, the molecular mechanisms of gonadal degeneration remain unclear.
Biwei Wu +4 more
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Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis. [PDF]
Front Neuroendocrinol, 2014 The hypothalamo-pituitary-adrenal (HPA) axis represents a complex neuroendocrine feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its function is the paraventricular nucleus of the hypothalamus (PVN) where neurons expressing corticotropin releasing factor reside.
Handa RJ, Weiser MJ.
europepmc +4 more sources
Are gonadal steroid hormones involved in disorders of brain aging? [PDF]
Aging Cell, 2003 SummaryHuman aging is associated with a decrease of circulating gonadal steroid hormones. Since these hormones act as trophic factors for neurones and glia, it is possible that the decrease in sex steroid levels may contribute to the increased risk of neurodegenerative disorders with advanced age.
Inigo Azcoitia +2 more
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Role of StAR Gene in Sex Steroid Hormone Regulation and Gonadal Development in Ark Shell Scapharca broughtonii [PDF]
BiologyThis study elucidates the role of the steroidogenic acute regulatory protein (StAR) in sex steroid hormone dynamics and the gonadal development of the commercially important marine bivalve ark shell Scapharca broughtonii.
Wenjing Wang +9 more
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The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development [PDF]
Neuroscience and Biobehavioral Reviews, 2016 Kalynn M Schulz, Cheryl L Sisk
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