Results 51 to 60 of about 86,509 (257)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Making sense of ICD-11 diagnostic criteria of compulsive sexual behavioural disorder

Annals, Academy of Medicine, Singapore
Compulsive sexual behaviour disorder (CSBD) is identified by persistent, intense sexual urges that lead to repetitive activities, causing significant distress or impairment over 6 months or more.1 It is characterised by neglecting important ...
Syidda Amron, Kandasami Gomathinayagam, Cheng Lee, Song Guo, Hui Shan Tan   +4 more
doaj   +1 more source

Analysis of criminal behaviour of serial perpetrators of the crime of rape [PDF]

NBP: Nauka, bezbednost, policija, 2017
Bearing in mind the fact that criminal behaviour is conditioned by the action of both cognitive and conative factors, the basic assumption we have started from in the research was that in the individual series the rapists had shown a clear individual ...
Baić Valentina, Lajić Oliver
doaj  

Modifying sexual behaviour of patients attending human immunodeficiency virus treatment centres in lagos

Nigerian Postgraduate Medical Journal, 2015
Aims and Objectives: This study was carried out among patients attending human immunodeficiency virus (HIV) treatment centres in Lagos to assess their sexual behaviour, conduct a health education intervention on safe sexual behaviour among the patients ...
Modupe Rebekah Akinyinka, Kikelomo Ololade Wright, Wole Alakija, Adeola Olatokunbo Apoola, Esther Oluwakemi Oluwole   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Caracterización de aspectos en la seguridad de la sexualidad en el anciano Characterization of the aspects on the safety of sexuality in the elderly

Revista de Ciencias Médicas de Pinar del Río, 2012
Se realizó un estudio descriptivo, transversal y prospectivo con el objetivo de caracterizar aspectos en la seguridad de la sexualidad en ancianos pertenecientes a dos Consultorios Médicos del Policlínico Universitario "Hermanos Cruz" de Pinar del Río en
María Valle Hernández, Joaquín Pérez Labrador, Esperanza Pozo Madera, Raisa Cristina Arcia Conill, Dianelis Pando Camejo   +4 more
doaj  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Perceived HIV-protective benefits of male circumcision: Risk compensatory behaviour among women in Malawi.

PLoS ONE, 2019
BACKGROUND:Male circumcision (MC) reduces men's risk of contracting HIV by approximately 60% and has the potential to significantly alter HIV epidemics.
Blessings Msango Kapumba, Rebecca King
doaj   +1 more source

The knowledge-risk-behaviour continuum among young Ugandans: what it tells us about SRH/HIV integration

BMC Public Health, 2019
Background With a human immunodeficiency virus (HIV) prevalence of 2.1% among 15–24 year olds, opportunities for further integration of sexual and reproductive health (SRH) and HIV prevention services for young people in Uganda exist.
Raquel Palomino González, Damazo Twebaze Kadengye, Roy William Mayega   +2 more
doaj   +1 more source