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Sexual differentiation of the brain and behavior
During the intrauterine period the human brain develops in the male direction via direct action of a boy's testosterone, and in the female direction through the absence of this hormone in a girl. During this time, gender identity (the feeling of being a man or a woman), sexual orientation, and other behaviors are programmed.
Dick F Swaab
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Sexual Differentiation of the Human Hypothalamus
Functional sex differences in reproduction, gender and sexual orientation and in the incidence of neurological and psychiatric diseases are presumed to be based on structural and functional differences in the hypothalamus and other limbic structures. Factors influencing gender, i.e., the feeling to be male or female, are prenatal hormones and compounds
Swaab, Dick F. +4 more
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Sexual differentiation in fission yeast
The regulation of sexual reproduction in yeast constitutes the highest level of differentiation observed in these unicellular organisms. The various ramifications of this system involve DNA rearrangement, transcriptional control, post-translational modification (such as protein phosphorylation) and receptor/signal processing.
R, Egel, O, Nielsen, D, Weilguny
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Journal of endocrinological investigation, 2004
Abstract Sexual differentiation is a sequential process that begins at fertilization with the establishment of chromosomal sex, continues with the determination of gonadal sex, and culminates in the development of secondary sexual characteristics that comprise the male and female phenotypes. This basic paradigm (Fig.
A A, Sinisi +3 more
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Abstract Sexual differentiation is a sequential process that begins at fertilization with the establishment of chromosomal sex, continues with the determination of gonadal sex, and culminates in the development of secondary sexual characteristics that comprise the male and female phenotypes. This basic paradigm (Fig.
A A, Sinisi +3 more
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DISORDERS OF SEXUAL DIFFERENTIATION
Endocrinology and Metabolism Clinics of North America, 1998An infant born with ambiguous genitalia requires an accurate and prompt diagnosis so that a management plan can be formulated. This article discusses the signaling cascade of genes that controls sexual differentiation. Clinical disorders involving sex reversal or ambiguous genitalia are discussed in relation to the genes regulating sexual development ...
G L, Warne, J D, Zajac
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Sexual determination and sexual differentiation
Critical Reviews in Plant Sciences, 1990(1990). Sexual determination and sexual differentiation. Critical Reviews in Plant Sciences: Vol. 9, No. 4, pp. 295-316.
Raymonde Durand +2 more
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Disorders of Sexual Differentiation
Surgical Pathology Clinics, 2010The term, disorders of sexual differentiation, broadly represents a disjunction between genotype and phenotype. Phenotype in turn can refer to external or internal genital development. Disorders of sexual differentiation are determined at conception insofar as (1) the abnormal genotype is the aberrant genetic product of fertilization at the chromosomal
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Sexual Differentiation of the Brain
Hospital Practice, 1978Ontogenetically the brain is female and, regardless of genetic sex, would remain so if not exposed to gonadal hormones at a critical stage in its development. Research in animals in which this exposure occurs after birth is providing evidence that the differentiation of the neural substrates that regulate pituitary activity and sexual behavior is ...
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During the intrauterine period a testosterone surge masculinizes the fetal brain, whereas the absence of such a surge results in a feminine brain.
Ai-Min Bao, Dick F Swaab
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