Results 51 to 60 of about 124,493 (301)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

The Effect of Target Sex, Sexual Dimorphism, and Facial Attractiveness on Perceptions of Target Attractiveness and Trustworthiness

Frontiers in Psychology, 2018
Facial sexual dimorphism has widely demonstrated as having an influence on the facial attractiveness and social interactions. However, earlier studies show inconsistent results on the effect of sexual dimorphism on facial attractiveness judgments ...
Yuanyan Hu, Yuanyan Hu, Najam ul Hasan Abbasi, Yang Zhang, Hong Chen, Hong Chen   +5 more
doaj   +1 more source

Exploring protandry and pupal size selection for Aedes albopictus sex separation [PDF]

, 2018
Background: We explored the possibility to improve male/female separation (sexing) in Aedes albopictus by selection of two strains, one toward increasing sex dimorphism and another toward increasing protandry.
Balestrino, Fabrizio, Bellini, Romeo, Carrieri, Marco, Puggioli, Arianna, Urbanelli, Sandra   +4 more
core   +1 more source

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

Can sexual selection drive female life histories? A comparative study on Galliform birds [PDF]

, 2007
Sexual selection is an important driver of many of the most spectacular morphological traits that we find in the animal kingdom (for example see Andersson, 1994). As such, sexual selection is most often emphasized as
A. Ø. MOOERS, Andersson M., Bennett P.M., Bininda-Emonds O.R.P., Blackburn T.M., Blackburn T.M., Cornishbowden A., Cramp S., Crowe T.M., Crowe T.M., del Hoyo J., Dunning J.B., E. J. A. CUNNINGHAM, Ellsworth D.L., Gutierrez R.J., Gutierrez R.J., Harvey P.H., Heath D.D., Holman H.J., Hoyt D.F., J. J. VERSPOOR, Lack D., Lack D., Maddison W.P., Midford P.E., Munechika I., N. KOLM, Nylander J.A.A., R. W. STEIN, Roff D.A., Roff D.A., Rohwer F.C., Rohwer F.C., Sibley C.G., Sikes D.S., Stearns S.C., Swofford D.L., Wen L.-Y., Zhan X.-J., Zink R.M.   +39 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A genetic test of sexual size dimorphism in pre-emergent chinook salmon. [PDF]

PLoS ONE, 2013
Sex differences in early development may play an important role in the expression of sexual size dimorphism at the adult stage. To test whether sexual size dimorphism is present in pre-emergent chinook salmon (Oncorhynchus tshawytscha), alevins were ...
Tosh W Mizzau, Shawn R Garner, Stephen A C Marklevitz, Graham J Thompson, Yolanda E Morbey   +4 more
doaj   +1 more source

Temporal discrimination: Mechanisms and relevance to adult-onset dystonia [PDF]

, 2017
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Beck, Rebecca, Conte, Antonella, Hutchinson, Michael, Killian, Owen, Mcgovern, Eavan M., Narasimham, Shruti, O'Riordan, Sean, Reilly, Richard B.   +7 more
core   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Sex-biased phenotypic plasticity affects sexual dimorphism patterns under changing environmental conditions

Scientific Reports
Sexual dimorphism is almost ubiquitous in animals. A common pattern observed across multiple taxa involves differences in development time (sexual bimaturism) and body size (sexual size dimorphism) between conspecific males and females.
Giulia Cordeschi, Daniele Canestrelli, Daniele Porretta   +2 more
doaj   +1 more source