Results 41 to 50 of about 914,664 (294)

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

open access: yesAdvanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu   +13 more
wiley   +1 more source

Sexual dimorphism and ancestral variation in the pectoral and pelvic girdles of modern humans

open access: yesHomo, 2023
Discussions of the evolution of sexual dimorphism in torso shape and the pectoral region assume that this dimorphism exists independently of body size.
Daphne R. Hudson, John H. Langdon
doaj   +1 more source

Sexual Dimorphism in the Chinese Endemic Species Hynobius maoershanensis (Urodela: Hynobiidae)

open access: yesAnimals, 2022
Sexual dimorphism is common in most vertebrate species and has diverse manifestations. The study of sexual dimorphism has critical significance for evolutionary biological and ecological adaptation.
Huiqun Chen   +5 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

open access: yesAdvanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Sexual Dimorphism in Fin Size and Shape in North American Killifish

open access: yesEcology and Evolution
Sexual dimorphism is intriguing because it suggests that males and females differ in phenotypic optima for traits and that sex‐specific trait values can evolve despite a shared genome.
Elijah J. Davis   +3 more
doaj   +1 more source

Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver

open access: yesFrontiers in Physiology, 2018
Sexual size dimorphism is an interesting phenomenon occurred in many fish species. Wildtype zebrafish exhibits a significant sexual dimorphism in body size at the adult stage.
Peipei Huang   +5 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

open access: yesAdvanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh   +22 more
wiley   +1 more source

Morphometric differentiation and sexual dimorphism in Limnomedusa macroglossa (Duméril & Bibron, 1841) (Anura: Alsodidae) from Uruguay

open access: yesActa Herpetologica, 2021
Intersexual morphological differences within a species occur in many traits, including body size and shape. Many processes that cause geographic variability in morphology have been proposed: population structure, phenotypic plasticity (environmental ...
Valeria de Olivera-López   +2 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

Facial and body sexual dimorphism are not interconnected in the Maasai

open access: yesJournal of Physiological Anthropology, 2022
Background In this paper, we investigate facial sexual dimorphism and its’ association with body dimorphism in Maasai, the traditional seminomadic population of Tanzania.
Marina L. Butovskaya   +2 more
doaj   +1 more source

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