Results 51 to 60 of about 125,407 (302)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The Effect of Target Sex, Sexual Dimorphism, and Facial Attractiveness on Perceptions of Target Attractiveness and Trustworthiness

Frontiers in Psychology, 2018
Facial sexual dimorphism has widely demonstrated as having an influence on the facial attractiveness and social interactions. However, earlier studies show inconsistent results on the effect of sexual dimorphism on facial attractiveness judgments ...
Yuanyan Hu, Yuanyan Hu, Najam ul Hasan Abbasi, Yang Zhang, Hong Chen, Hong Chen   +5 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source

Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development

Nature Communications
In mammals, sexual size dimorphism often reflects the intensity of sexual selection, yet its connection to genomic evolution remains unexplored. Gene family size evolution can reflect shifts in the relative importance of different molecular functions ...
Benjamin Padilla-Morales, Alin P. Acuña-Alonzo, Huseyin Kilili, Atahualpa Castillo-Morales, Karina Díaz-Barba, Kathryn H. Maher, Laurie Fabian, Evangelos Mourkas, Tamás Székely, Martin-Alejandro Serrano-Meneses, Diego Cortez, Sergio Ancona, Araxi O. Urrutia   +12 more
doaj   +1 more source

A genetic test of sexual size dimorphism in pre-emergent chinook salmon. [PDF]

PLoS ONE, 2013
Sex differences in early development may play an important role in the expression of sexual size dimorphism at the adult stage. To test whether sexual size dimorphism is present in pre-emergent chinook salmon (Oncorhynchus tshawytscha), alevins were ...
Tosh W Mizzau, Shawn R Garner, Stephen A C Marklevitz, Graham J Thompson, Yolanda E Morbey   +4 more
doaj   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Separating sexual dimorphism from other morphological variation in a specimen complex of fossil marine reptiles (Reptilia, Ichthyosauriformes, Chaohusaurus). [PDF]

, 2018
The Early Triassic Chaohu Fauna from Anhui Province, China, contains the oldest record of Mesozoic marine reptiles, such as Cartorhynchus and Sclerocormus.
Hu, Yuan-Chao, Huang, Jiandong, Jiang, Da-Yong, Motani, Ryosuke, Rieppel, Olivier, Tintori, Andrea, You, Hailu, Zhang, Rong   +7 more
core   +2 more sources

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Sex-biased phenotypic plasticity affects sexual dimorphism patterns under changing environmental conditions

Scientific Reports
Sexual dimorphism is almost ubiquitous in animals. A common pattern observed across multiple taxa involves differences in development time (sexual bimaturism) and body size (sexual size dimorphism) between conspecific males and females.
Giulia Cordeschi, Daniele Canestrelli, Daniele Porretta   +2 more
doaj   +1 more source