Results 51 to 60 of about 914,664 (294)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

XiangyiLi/Sexual-dimorphism-driven-by-intersexual-resource-competition: SexualDimorphismEvolutionSimulation

open access: yes, 2021
This is the final code for the individual-based simulation model that accompany the paper "Sexual dimorphism driven by intersexual resource competition: why it is rare, and where to look for it?" by Xiang-Yi Li and Hanna Kokko, published on Journal of ...
Xiang-Yi Li
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

open access: yesAdvanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He   +10 more
wiley   +1 more source

The Effect of Target Sex, Sexual Dimorphism, and Facial Attractiveness on Perceptions of Target Attractiveness and Trustworthiness

open access: yesFrontiers in Psychology, 2018
Facial sexual dimorphism has widely demonstrated as having an influence on the facial attractiveness and social interactions. However, earlier studies show inconsistent results on the effect of sexual dimorphism on facial attractiveness judgments ...
Yuanyan Hu   +5 more
doaj   +1 more source

Sexual dimorphism in diaphyseal cross-sectional shape in the Medieval Muslim population of Écija, Spain and Anglo-Saxon Great Chesterford, UK

open access: yes, 2009
Differences in adult male and female activity patterns may influence levels of sexual dimorphism in physical dimensions, including the cross-sectional shape of long bone diaphyses.
Pomeroy, Emma, Zakrzewski, Sonia R.
core   +1 more source

Sexual dimorphism in the loud calls of Azara’s owl monkeys (Aotus azarae): evidence of sexual selection? [PDF]

open access: yes, 2019
Primates use different types of vocalizations in a variety of contexts. Some of the most studied types have been the long distance or loud calls. These vocalizations have been associated with mate defense, mate attraction, and resource defense, and it is
Huck, Maren   +5 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

open access: yesAdvanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang   +11 more
wiley   +1 more source

Sexual Dimorphism

open access: yesAnnual Review of Anthropology, 1985
doi:10.1146/annurev.an.14.100185.002241 ; Annual Review of Anthropology http://arjournals.annualreviews.org/loi ...
Frayer, David W., Wolpoff, Milford H.
openaire   +3 more sources

Sex-biased phenotypic plasticity affects sexual dimorphism patterns under changing environmental conditions

open access: yesScientific Reports
Sexual dimorphism is almost ubiquitous in animals. A common pattern observed across multiple taxa involves differences in development time (sexual bimaturism) and body size (sexual size dimorphism) between conspecific males and females.
Giulia Cordeschi   +2 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

open access: yesAdvanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian   +12 more
wiley   +1 more source

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