Results 51 to 60 of about 39,975 (260)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Sexual dimorphism in the incidence of human cancers

BMC Cancer, 2019
Background Sex differences in the incidences of cancers become a critical issue in both cancer research and the development of precision medicine. However, details in these differences have not been well reported.
Daoshan Zheng, Justyna Trynda, Cecilia Williams, Jeremy A. Vold, Justin H. Nguyen, Denise M. Harnois, Sanjay P. Bagaria, Sarah A. McLaughlin, Zhaoyu Li   +8 more
doaj   +1 more source

Female‐Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital‐Based Cohort Study From the Taiwan Precision Medicine Initiative

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Bitter taste receptors (T2Rs) function in the innate immune defense of the sinonasal mucosa; however, the genetic association between the TAS2R gene family and chronic rhinosinusitis (CRS) remains understudied in Asian populations.
Rong‐San Jiang, Man‐Wei Hua, I‐Chieh Chen, Yi‐Ming Chen, Shun‐Hung Lin, Kuan‐Yu Lai, Yi‐Chen Chen   +6 more
wiley   +1 more source

Sexual dimorphism for juvenile body weight in chickens divergently selected for 8-week body weight

Frontiers in Physiology
There is a dearth of literature on the genetics of sexual dimorphism for juvenile body weight in meat-type chickens given its biological and economic relevance. Herein, we report the sexual dimorphism for 4- and 8-week body weights in White Plymouth Rock
Paul B. Siegel, Christa F. Honaker
doaj   +1 more source

Sexual dimorphism of head, teeth, flipper and body size in northern elephant seals (Mirounga angustirostris) throughout ontogeny [PDF]

Royal Society Open Science
Sexual dimorphism, the difference in appearance between males and females of the same species, can shape physiology, behaviour and fitness. Yet, few species have age- and sex-specific data to characterize its development.
Madeleine R. Stewart, Stephanie K. Adamczak, Salma T. Abdel-Raheem, Daniel P. Costa, Roxanne S. Beltran   +4 more
doaj   +1 more source

A genetic test of sexual size dimorphism in pre-emergent chinook salmon. [PDF]

PLoS ONE, 2013
Sex differences in early development may play an important role in the expression of sexual size dimorphism at the adult stage. To test whether sexual size dimorphism is present in pre-emergent chinook salmon (Oncorhynchus tshawytscha), alevins were ...
Tosh W Mizzau, Shawn R Garner, Stephen A C Marklevitz, Graham J Thompson, Yolanda E Morbey   +4 more
doaj   +1 more source

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

The Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source

Age-related sexual dimorphism in temporal discrimination and in adult-onset dystonia suggests GABAergic mechanisms.

Frontiers in Neurology, 2015
Background: Adult onset isolated focal dystonia presenting in early adult life is more frequent in men whereas in middle age it is female predominant.
John S. Butler, Ines M Beiser, Ines M Beiser, Laura eWilliams, Laura eWilliams, Eavan eMcGovern, Eavan eMcGovern, Fiona eMolloy, Tim eLynch, Daniel G Healy, Helena eMoore, Richard eWalsh, Richard B Reilly, Richard B Reilly, Sean eO'Riordan, Sean eO'Riordan, Cathal eWalsh, Cathal eWalsh, Michael eHutchinson, Michael eHutchinson   +19 more
doaj   +1 more source

Revisiting paravertebral muscles in European rabbits (Oryctolagus cuniculus) and European brown hares (Lepus europaeus) (Leporidae; Lagomorpha)

The Anatomical Record, EarlyView.
Abstract Domesticated European rabbits (Oryctolagus cuniculus) have long been chosen as laboratory model organisms. Despite this, there has been no definitive study of the vertebral musculature of wild rabbits. Relevant descriptions of well‐studied veterinary model mammals (such as dogs) are generally applicable, but not appropriate for a species ...
Nuttakorn Taewcharoen, Emma Sherratt, Philip Stott, Rachel Norris   +3 more
wiley   +1 more source