Results 161 to 170 of about 38,910 (263)

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Sexual function and its associations with anxiety, depression, functionality, and quality of life in women with lipedema. [PDF]

Sex Med
Meral HB, Tolu S, Ketenci BM, Noyan Z, Rezvani A.   +4 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Sexual Experience, Psychological Implications, and Typical Response Strategies Among Childhood Cancer Survivors With Sexual Dysfunction in China: A Qualitative Study. [PDF]

Psychooncology
Yang F, Ho KY, Ji Y, Zhai Y, Zuo W, Liu X, Wang L, Wai Lam KK, Liu Q, Mao T, Tsoi Cheng FW, Fai NGC, Shi H, Wang Q, Wong FK, Yorke J.   +15 more
europepmc   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Adiposity and domain-specific menopausal symptom severity in midlife women: a cross-sectional clinical study in eastern china. [PDF]

Front Med (Lausanne)
Deng M, Zhang H, Zhang Z, Chen N.
europepmc   +1 more source

035 Variations in the Agreement between Subjective and Physiological Sexual Arousal among Women With and Without Sexual Dysfunction: The Moderating Role of Interoception

The Journal of Sexual Medicine, 2019
A. Handy, B. Freihard, L. Zaleta, C. Meston   +3 more
openaire   +1 more source

Guidelines for High‐Throughput Screening for Natural Products With Anti‐Aging Activity Based on Drosophila Intestinal Homeostasis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Aging represents a critical risk factor for chronic diseases, driving an urgent demand for interventions promoting healthy longevity. This study establishes standardized guidelines for high‐throughput screening (HTS) of anti‐aging natural products using Drosophila melanogaster, leveraging its intestinal homeostasis as a biomarker.
Xiao Sheng, Lei Zhang
wiley   +1 more source

Multidisciplinary Approach to Sexual Dysfunction in Persons With Lung Cancer-Spanish Lung Cancer Group Expert Consensus Statement. [PDF]

JTO Clin Res Rep
Ospina-Serrano AV, Maximiano-Alonso C, Guillén-Sentís P, Losada B, Cruz-Castellanos P, López-Castro R, Campos-Balea B, Azkona-Uribelarrea E, Cardeña A, Valdivia A, Olivares-Hernández A, Blasco-Cordellat A, Sereno-Moyano M, Peralta-Tanco D, Dómine M, Romão R, Muñoz-Borrajo S, Garcia-Espantaleon M, Pereira-Sánchez A, Fernández-Pascual E, Torremadé-Barreda J, Montejo AL, Larrazabal M, Martin-Romo CC, Alvarez-Garcia R, Sánchez F, Calvo V, Provencio-Pulla M.   +27 more
europepmc   +1 more source