Results 171 to 180 of about 107,736 (307)

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

open access: yesAdvanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman   +15 more
wiley   +1 more source

Induction of puberty in hypogonadal forms of primary amenorrhoea: current evidence and future perspectives. [PDF]

open access: yesEndocr Connect
Profka E   +6 more
europepmc   +1 more source

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

open access: yesAdvanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang   +15 more
wiley   +1 more source

From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management. [PDF]

open access: yesFront Cell Dev Biol
Wang B   +9 more
europepmc   +1 more source

Species Dependent Toxicity Comparison Outcome

open access: yesAdvanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao   +7 more
wiley   +1 more source

Single potential analysis of cavernous electric activity [PDF]

open access: yes, 1990
C. G. Stief   +18 more
core   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

open access: yesAdvanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou   +8 more
wiley   +1 more source

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