Results 31 to 40 of about 115,986 (262)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Sexual Dysfunction in Women With Multiple Sclerosis: Expectations Regarding Treatment and Information, and Utility of the SEA-MS-F Questionnaire

Sexual Medicine, 2022
Introduction: Sexual dysfunction is a common complaint in female with multiple sclerosis (MS), however this problem is not often considered in the medical and psychological care.
Schreiber-Bontemps Audrey, MD, Roquet Marion, MD, Médée Béatrice, MD, Verdun Stéphane, Hubeaux Katelyne, MD   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age

Sexual Medicine, 2018
Introduction: Human T-lymphotropic virus (HTLV)-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder that mostly affects women.
Adenilda Lima Lopes Martins, MD, PhD, Maria Fernanda Rios Grassi, MD, PhD, Alisson de Aquino Firmino, MSc, Jean Paulo Lacerda Araujo, UGS, Taiane Silva Paixao, UGS, Bernardo Galvão-Castro, MD, PhD, Ney Boa-Sorte, MD, PhD   +6 more
doaj   +1 more source

Sexual Dysfunction Among Young Adults in Sweden—A Population-Based Observational Study

Sexual Medicine, 2020
Introduction: There is a lack of studies using validated instruments to investigate prevalence and predictors of sexual dysfunction among young adults.
Lisa Ljungman, PhD, Claudia Lampic, PhD, Lena Wettergren, PhD, RN   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Antipsychotics and Sexual Dysfunction: Sexual Dysfunction - Part III

Online Journal of Health & Allied Sciences, 2009
Satisfying sexual experience is an essential part of a healthy and enjoyable life for most people. Antipsychotic drugs are among the various factors that affect optimal sexual functioning.
Anil Kumar Mysore Nagaraj, Nagesh Brahmavar Pai, Satheesh Rao   +2 more
doaj  

Assessment of Sexual Health Knowledge, Attitudes, Practices and Dysfunction in Women Attending Obstetrics and Gynaecology OPD

Journal of Psychosexual Health
Background: Despite the fact that there have been significant advances in the prevention and treatment of sexual dysfunction in India, the majority of these have focused on male sexual dysfunction disorders and there is still a paucity of literature that
Bhumika Mishra, Sujatha MS, T S S Rao
doaj   +1 more source

Does post-acute COVID-19 syndrome women's sex problems link to psychiatry after 6 months?

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Background Few data about women's sexuality practices post-acute COVID-19 syndrome are available. Many women who have had the disease experience sexual dysfunction; hence, the adverse effect of COVID-19 on sexual function has generated interest. We aimed
Rofaida Refaat Shehata, Gellan K. Ahmed, Aliae A. R. Mohamed Hussien, Manal A. Mahmoud   +3 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source