Results 91 to 100 of about 190,186 (350)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Genome-wide circular RNAs signatures involved in sexual maturation and its heterosis in chicken

Journal of Integrative Agriculture
Sexual maturation heterosis has been widely exploited in animal crossbreeding. However, the underlying mechanism has been rarely explored in chicken. In the present study, we performed the reciprocal crossing between White Leghorn and Beijing You chicken
Yuanmei Wang, Jingwei Yuan, Yanyan Sun, Aixin Ni, Jinmeng Zhao, Yunlei Li, Panlin Wang, Lei Shi, Yunhe Zong, Pingzhuang Ge, Shixiong Bian, Hui Ma, Jilan Chen   +12 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genome-Wide Analysis and Function Prediction of Long Noncoding RNAs in Sheep Pituitary Gland Associated with Sexual Maturation [PDF]

, 2020
Hua Yang, Jianyu Ma, Zhibo Wang, Xiaolei Yao, Jie Zhao, Xinyue Zhao, Feng Wang, Yanli Zhang   +7 more
openalex   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Allometric scaling of aerobic fitness outputs in school-aged pubertal girls

BMC Pediatrics, 2019
Background This study aimed to determine the allometric exponents for concurrent size descriptors (stature, body mass and fat-free mass) and also to examine the contribution of chronological age and pubertal status combined with above mentioned size ...
André O. Werneck, Jorge Conde, Manuel J. Coelho-e-Silva, Artur Pereira, Daniela C. Costa, Diogo Martinho, João P. Duarte, João Valente-dos-Santos, Rômulo A. Fernandes, Mariana B. Batista, David Ohara, Edilson S. Cyrino, Enio R. V. Ronque   +12 more
doaj   +1 more source

A note on the von Bertalanffy growth function concerning the allocation of surplus energy to reproduction [PDF]

, 2012
We propose an extended form of the von Bertalanffy growth function (VBGF), where the allocation of surplus energy to reproduction is considered. Any function can be used in our model to describe the ratio of energy allocation for reproduction to that ...
Akamine, Tatsuro, Ohnishi, Shuhei, Okamura, Hiroshi, Yamakawa, Takashi   +3 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Influence of sexual maturation on anaerobic performance of male adolescent wrestlers

Revista de Artes Marciales Asiáticas
This study aimed to examine the impact of sexual maturation on the anaerobic performance of male adolescent wrestlers. Methods: We included a sample of 29 freestyle and Greco-Roman wrestlers from various clubs in Barinas, Venezuela.
Yudelis Leonardo Torres-Álvarez, Pedro Felipe Gamardo-Hernández, Bianka Miarka   +2 more
doaj   +1 more source