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ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
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Abstract Premature sexual maturation is a frequent cause for referral in paediatric endocrinology. Although clinical evaluation will suffice to reassure the patient and family in a majority of cases, premature sexual maturation can reveal severe conditions and need a thorough evaluation to identify its cause and potential for progression,
Jean-Claude Carel, Juliane Léger
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Reproduction in Domestic Animals, 2008
ContentsIn this review, we describe the process of sexual maturation in the bull calf. The testes of the bull grow relatively slowly until approximately 25 weeks of age and then a rapid phase of growth occurs until puberty, at 37–50 weeks of age. During the early postnatal phase of slower growth of the testis pre‐spermatogonia and some spermatogonia ...
N, Rawlings +3 more
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ContentsIn this review, we describe the process of sexual maturation in the bull calf. The testes of the bull grow relatively slowly until approximately 25 weeks of age and then a rapid phase of growth occurs until puberty, at 37–50 weeks of age. During the early postnatal phase of slower growth of the testis pre‐spermatogonia and some spermatogonia ...
N, Rawlings +3 more
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Sexual Maturation in Thai Boys
Journal of Pediatric Endocrinology and Metabolism, 2010A worldwide secular trend towards earlier onset of puberty in girls has been noted during recent years. However, the data on sexual maturation of boys are relatively scarce and normative data of sexual maturation in Thai boys are still lacking.To determine the age of secondary sexual maturation in normal Thai boys.Three hundred healthy urban boys aged ...
P, Mahachoklertwattana +5 more
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Etiologies of Sexual Maturation: A Model System Based on the Sexually Maturing Rat
1976Publisher Summary This chapter discusses the etiologies of sexual maturation based on the studies performed in postulated models in rats and children. The chapter outlines the changes in blood in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) during maturation in rats and other animal models.
W D, Odell, R S, Swerdloff
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The ovary and sexual maturation of the brain
Development, 1967ABSTRACT Pfeiffer (1935, 1936) reported the induction of constant oestrus in female rats following the transplantation of testes from litter-mate males just after birth and noted that the ovaries of these animals did not contain corpora lutea. These changes remained after removal of the testis transplants.
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Light intensity and sexual maturity
American Journal of Physical Anthropology, 1969AbstractThere are confirmable clines, by latitude, of melanin concentration in pigmentation for man as well as other mammals and birds. This has been suggested to be, in man, a result of the importance of vitamin D synthesis which can be inhibited by darker skins in higher latitudes.
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Diagnosis of Disorders of Sexual Maturation
Pediatric Clinics of North America, 1971A review of normal pubertal development with recent statistical findings on the timing of the events of puberty precedes a discussion of useful laboratory tests that measure hormones and their application to the differential diagnosis of disorders of sexual maturation.
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