Results 111 to 120 of about 244,987 (304)

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Transcriptome Sequencing and Differential Analysis of Testes of 1-Year-Old and 3-Year-Old Kazakh Horses

Biology
The Kazakh horse is an outstanding dual-purpose dairy and meat breed in China, characterized by early maturity, tolerance to coarse feed, and strong stress resistance.
Jiahao Liu, Yuting Yang, Liuxiang Wen, Mingyue Wen, Yaqi Zeng, Wanlu Ren, Xinkui Yao   +6 more
doaj   +1 more source

Length at maturity in three pelagic sharks (Lamna nasus, Isurus oxyrinchus, and Prionace glauca) from New Zealand [PDF]

, 2005
Reproductive data collected from porbeagle, shortfin mako, and blue sharks caught around New Zealand were used to estimate the median length at maturity.
Duffy, Clinton, Francis, Malcolm P.
core  

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Gonadal development and sexual maturity onset of giant gourami (Osphronemus Goramy Lac.)

Discover Animals
The giant gourami is herbivorous freshwater fish native in Southeast Asia which have great economic importance, particularly within Indonesia’s aquaculture industry.
Ayu Luthfiyah Purnamasari, Rustadi, Ignatius Hardaningsih, Ardaning Nuriliani, Harya Bimasuci, Mohamad Aji Ikhrami, Dini Wahyu Kartika Sari   +6 more
doaj   +1 more source

Onboard sampling of the rockfish and lingcod commerical passenger fishing vessel industry in northern and central California, 1992 [PDF]

, 1996
In 1992 fishery technicians sampled 230 commercial passenger fishing vessel (CPFV) trips targeting rockfish and lingcod from the port areas of Fort Bragg, Bodega Bay, San Francisco, Monterey, and Morro Bay.
Halko, Laura A., Reilly, Paul N., Wilson, Carrie E., Wilson-Vandenberg, Deb   +3 more
core  

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

Allometric growth pattern, sexual dimorphism and size at the onset of sexual maturity in Opusia indica (Brachyura: Ocypodoidea: Camptandriidae) from mangrove areas of Pakistan

International Journal of Aquatic Biology, 2016
Size at sexual maturity and patterns of somatic growth are important aspects of reproductive history of crab. The main purpose of this study is to provide an estimate for the onset of morphological sexual maturity in mangrove crab, Opusia indica from a ...
Noor Us Saher, Naureen Aziz Qureshi, Uroj Aziz   +2 more
doaj