Results 61 to 70 of about 60,101 (292)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Sexual Behaviors and Its Predictors among Iranian Women Living in Kashan City 2017: A Cross-Sectional Study [PDF]

open access: yesInternational Journal of Fertility and Sterility, 2018
Background Women’s sexual well-being has been the center of attention in the field of sexology. Study of sexual behavior and investigating its predictors are important for women’s health promotion. This study aimed to explore the components of women’s
Zahra Karimian   +4 more
doaj   +1 more source

Pro-Sexual Effects of Aqueous and Methanol Extracts of Phyllanthus muellerianus (Kuntze) Exell (Phyllanthaceae) on a Model of Low Sexual Desire Disorder in Female Rats

open access: yesTraditional and Integrative Medicine, 2022
Low sexual desire disorder is a recurrent deficiency in desire for sexual activity which impairs lifestyle. It is a frequent problem in women with limited therapeutic options.
Esther Ngadjui   +6 more
doaj   +1 more source

Success Attributions and More: Multidimensional Extensions of the Sexual Attribution Bias to Failure Attributions, Social Emotions, and the Desire for Social Interaction [PDF]

open access: yes, 2008
According to the recently discovered sexual attribution bias (SAB), young adults attribute the success of same-aged, same-sex attractive stimulus persons in a more derogative way than the success of less attractive same-sex persons, whereas this pattern ...
Spörrle, Matthias   +2 more
core   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi   +17 more
wiley   +1 more source

An overview of the literature on female-perpetrated adult male sexual victimization [PDF]

open access: yes, 2013
The rape of women has been an issue of concern in research literature for the past 40 years. Conversely, rape against men has only relatively recently received investigation.
Fisher, Nicola L., Pina, Afroditi
core   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay   +13 more
wiley   +1 more source

The Sexual Incentive Motivation Model and Its Clinical Applications [PDF]

open access: yes, 2022
Sexual motivation (desire) requires the simultaneous presence of an active central motive state and a stimulus with sexual significance. Once activated, sexual motivation leads to visceral responses and approach behaviors directed toward the emitter of
Ågmo, Anders j   +3 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Silencing and stimulating the medial amygdala impairs ejaculation but not sexual incentive motivation in male rats [PDF]

open access: yes, 2021
The medial amygdala (MeA) is a sexually dimorphic brain region that integrates sensory information and hormonal signaling, and is involved in the regulation of social behaviors. Lesion studies have shown a role for the MeA in copulation, most prominently
Heijkoop, Roy   +3 more
core   +1 more source

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