Results 181 to 190 of about 3,912 (263)

Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid. [PDF]

BMJ Open
Dunn S, Evans L, Kennedy C, Wafer R, Moody S, Wolstenhulme F, Burton E, Konkoth AB, Fisher H, Chadwick T, Banham A, Hale F, Christie M, Barclay ST, Dyson J, Smith R, Aithal G, Culver E, Aspinall R, Thorburn D, Heneghan M, Hancock HC, Trivedi P, Mells G, Wason J, Jones DEJ.   +25 more
europepmc   +1 more source

The Hinges of On Certainty

Theoria, EarlyView.
ABSTRACT Some commentators argue that the notes collected as Wittgenstein's On Certainty provide the basis for a groundbreaking epistemological theory and response to scepticism. This theory pertains to the role of what some have called the hinge propositions of our inquiry, following Wittgenstein's metaphor of hinges of a door. This paper examines one
David Veldran
wiley   +1 more source

Incomplete penetrance in inborn errors of immunity: A skeleton in the closet-The sequel. [PDF]

J Hum Immun
Bogunovic D.
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Broad-spectrum antiviral activity of ebselen. [PDF]

Sci Rep
Jitobaom K, Boonyuen U, Boonarkart C, Sirihongthong T, Auewarakul P.   +4 more
europepmc   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Novel gene variants in a rare case of SRY-negative 46, XX male syndrome with bone marrow failure by whole exome sequencing. [PDF]

Blood Sci
Zhang A, Liu L, Ruan M, Zhang L, Zou Y, Chen Y, Zhang Y, Yang W, Zhu X, Chang L.   +9 more
europepmc   +1 more source

Concept Creep and the Mental Health Crisis

Social Issues and Policy Review, Volume 20, Issue 1, December 2026.
ABSTRACT Many explanations have been offered for the rising prevalence of mental health complaints. I present an account that attributes some of this increase to historical changes in mental health‐related concepts that are propelled by broad cultural trends.
Nick Haslam
wiley   +1 more source

PRRSV-1 outbreak in a farrowing farm caused by a vaccine derived strain: a case report. [PDF]

Porcine Health Manag
Lebret A, Renson P, Brissonnier M, Chevance C, Normand V, Favrel J, Da-Costa JF, Jeusselin J, Nicolazo T, Blanchard Y, Bourry O, Boulbria G.   +11 more
europepmc   +1 more source

Addressing the Right to Food Through Food Expenditure Burdens: Distributional Evidence Among Low‐Income Farming Families in Brazil (2012–2023)

World Food Policy, Volume 12, Issue 2, November 2026.
ABSTRACT Household food expenditure continues to be a key factor in ensuring the realization of the Human Right to Adequate Food. Particularly in Brazil, access to food can be limited by economic constraints in vulnerable families, especially among farming families, who have been more vulnerable to food insecurity in recent years in the country.
Lucas de Almeida Moura, Flávia Mori Sarti, Carolina Ribeiro Xavier, Dirce Maria Lobo Marchioni   +3 more
wiley   +1 more source