A landscape of metabolic burden and its cardiovascular impact across the adult lifespan: a prospective cohort study of 7.5 million people in Northwestern China. [PDF]
Liu ZY +13 more
europepmc +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
The 19th St. Gallen international breast cancer conference 'primary therapy of patients with early breast cancer. Evidence, controversies, consensus': key moments and breakthroughs. [PDF]
Morigi C.
europepmc +1 more source
SYN‐A, a naturally derived synergist, inhibited key metabolic pathways associated with pyrethroid insecticide resistance in cabbage stem flea beetle (CSFB) and its parasitoid Microctonus brassicae. SYN‐A restored pyrethroid efficacy against resistant CSFB allowing up to 80% reduction in application rates.
Patricia A. Ortega‐Ramos +2 more
wiley +1 more source
Cytogenomic Investigation of Individuals with Ovotesticular Difference of Sex Development.
Lima-Santos J +12 more
europepmc +1 more source
What guidance exists to support remote consultations in sexual and reproductive health services? A review of the policy and practice literature. [PDF]
Spurway C +11 more
europepmc +1 more source
ABSTRACT Household food expenditure continues to be a key factor in ensuring the realization of the Human Right to Adequate Food. Particularly in Brazil, access to food can be limited by economic constraints in vulnerable families, especially among farming families, who have been more vulnerable to food insecurity in recent years in the country.
Lucas de Almeida Moura +3 more
wiley +1 more source
A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation. [PDF]
Prajapati SK +11 more
europepmc +1 more source
ABSTRACT Background Healthcare overuse, including unnecessary diagnostic testing and procedures, contributes to patient harm, increased healthcare costs, and resource waste. The Choosing Wisely initiative aims to reduce low‐value care through evidence‐based recommendations.
Emma Larsson +10 more
wiley +1 more source

