Results 71 to 80 of about 3,912 (263)

Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival

International Journal of Cancer, EarlyView.
ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li, Elaheh Zarean, Danmeng Lily Li, Yiyue Zhu, Shuai Li, Enes Makalic, Catriona McLean, Graham G. Giles, Roger L. Milne, Melissa C. Southey, Pierre‐Antoine Dugué   +10 more
wiley   +1 more source

Effect of 11β-hydroxyandrostenedione (OHA) on the gonadal differentiation in whitefish Coregonus lavaretus L.

Frontiers in Marine Science, 2015
Monosex stocks of fish become increasingly important in the aquaculture. In fish with male heterogamety, mating females with neo-males i.e. hormonally sex reversed (masculinized) females results in “all-female” stocks.
Piotr Hliwa, Konrad Ocalewicz
doaj   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Impact of cystic fibrosis transmembrane conductance regulator modulator therapies on liver stiffness and liver enzymes: An observational perspective single‐center cohort study

JPGN Reports, EarlyView.
Abstract Objectives The efficacy of cystic fibrosis transmembrane conductance regulator (CFTR)‐modulator therapies in preventing or ameliorating cystic fibrosis liver disease (CFLD) by correcting CFTR in cholangiocytes is not well‐documented. This study aimed to assess liver function during CFTR‐modulators.
Laura Giugliano, Elisabetta Augustoni, Antonio Pizzol, Anna Opramolla, Cristina Chiadò, Anna Zagaria, Irene Esposito, Giulia Roberto, Alice Ponte, Andrea Evangelista, Paola Quarello, Michele Pinon, Pier Luigi Calvo   +12 more
wiley   +1 more source

Seleção de matrizes e clones de mangabeira para o cultivo in vitro Selection of parents and clones of mangabeira for in vitro cultivation

Pesquisa Agropecuária Brasileira, 2004
Altas taxas de mortalidade em viveiro de mudas de mangabeira (Hancornia speciosa) impedem seu uso na reversão do processo de degradação das terras e na manutenção da produtividade e integridade ambiental do Cerrado.
Luana de Lima Machado, Maria Lucrécia Gerosa Ramos, Linda Styer Caldas, Lúcio José Vivaldi   +3 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Dynamic miRNA landscapes unlock sexual plasticity in protogynous orange-spotted grouper under MT-implantation

Aquaculture Reports
Sex change, a manifestation of sexual plasticity, is widespread among fish, yet its molecular regulatory mechanisms, particularly those involving miRNAs, remain largely unresolved.
Leyi Chang, Tongde Liu, Yuhao Tao, Yanzhao Zhao, Tong Wang, Xiaojing Wu, Qichuang Wei, Xi Wu, Xiaochun Liu   +8 more
doaj   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Masculinización de tilapia roja (Oreochromis spp) por inmersión utilizando 17 alfa–metiltestosterona Red tilapia (Oreochromis spp) masculinization by immersion using 17 alpha-methyltestosterone

Revista Colombiana de Ciencias Pecuarias, 2007
La tilapia roja (Oreochromis spp) es ampliamente producida a nivel mundial. Un inconveniente para su producción es la alta precocidad para la reproducción, lo que afecta su crecimiento y ocasiona la superpoblación.
Carlos A López, Dewin L Carvajal, Mónica C Botero   +2 more
doaj  

C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression.

PLoS Genetics, 2007
Chromosome inheritance during sexual reproduction relies on deliberate induction of double-strand DNA breaks (DSBs) and repair of a subset of these breaks as interhomolog crossovers (COs).
Michiko Hayashi, Gregory M Chin, Anne M Villeneuve   +2 more
doaj   +1 more source