Results 131 to 140 of about 2,105,134 (400)

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Physical and Psychological Violence at the Workplace [PDF]

, 2013
[Excerpt] Key findings Workplace violence is a social phenomenon of a certain magnitude. Overall, approximately 6% of European workers report having experienced some form of workplace violence, either physical or psychological, in the past 12 months ...
Eurofound
core   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Beyond Silence, Towards Refusal: The Epistemic Possibilities of #MeToo [PDF]

, 2019
There are many ways to understand the meanings of the #MeToo movement. Analyses of its significance have proliferated in popular media; some academic analyses have also recently appeared. Commentary on the philosophical and epistemic significance of the #
Miller, Sarah
core  

Comprehensive Sexuality Education as a Primary Prevention Strategy for Sexual Violence Perpetration

Trauma, Violence, & Abuse, 2020
Madeline Schneider, J. Hirsch
semanticscholar   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Development and implementation of a website assessment tool to evaluate policies and resources for sexual assault and alcohol use on US college campuses

BMC Global and Public Health
Background Sexual assault on college campuses is a major public health concern. Over half of incidents of sexual violence on college campuses occur in the context of victim or perpetrator alcohol use.
Elizabeth A. Walker, Regina Futcher, Naomi Segel, Nandana Menon, Julia Vroman, Alyssa E. Gribov, Kayla Ortiz, Robert W. S. Coulter, Christina F. Mair, Elizabeth Miller, Rachel E. Gartner   +10 more
doaj   +1 more source

Management of Family Education in Growing Anti-Sexual Violence Attitudes

ASANKA
Sexual violence against children is a crime that must be eliminated. This sexual violence has a negative impact on both physical and psychological aspects. Children are seen from two sides, namely children with potential as perpetrators and children with
Wilis Werdiningsih, Yekti Winursito
doaj   +1 more source

Intimate Partner Violence and Sexual Violence in the Yukon-Kuskokwim Delta: Key Results from the 2012 Alaska Victimization Survey [PDF]

, 2012
This document is a two-page summary of the key results from the 2012 Alaska Victimization Survey for the Yukon-Kuskokwim Delta of Alaska (Bethel Census Area and Kusilvak (formerly Wade Hampton) Census Area), which was conducted from March to May 2012 ...
Rosay, André B.
core