Results 111 to 120 of about 2,215,465 (390)
The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo
Advanced Science, EarlyView.We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge +14 more
wiley +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Child Protection and PracticeProducing and publishing research on violence against women (VAW) and violence against children (VAC) is essential for developing evidence-based solutions to these widespread issues.
Elizabeth Dartnall +4 more
doaj +1 more source
Descriptive Analysis of Domestic Violence and Sexual Assault Incidents Closed by the Alaska State Troopers: 2008–2011 — Final Report [PDF]
, 2015 This report presents a descriptive analysis of sexual assault and domestic violence incidents closed by the Alaska State Troopers for the period January 1, 2008 through December 31, 2011, as part of an effort to systematically document the formal ...
Myrstol, Brad A., Parker, Khristy L.
core
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Advanced Science, EarlyView.This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li +7 more
wiley +1 more source
Alaska Victimization Survey: Aleutian/Pribilof Islands [PDF]
, 2018 This article also appeared on p. 4 of the Spring 2018 print edition.This article provides an overview of key results from the 2014–2015 Alaska Victimization Survey (AVS) for the Aleutian/Pribilof Island region, which was conducted from April to June 2014
UAA Justice Center
core
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source