Results 141 to 150 of about 788,788 (345)

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Prevalence and factors influencing intimate partner sexual violence against women aged 15–49 in Kenya: findings from the 2022 Kenya demographic and health survey

BMC Women's Health
Background Sexual violence, a global concern, disproportionately affects women. In Kenya, over 40% of women experience intimate partner violence, reflecting a pressing need for understanding and addressing this issue.
Emmanuel Asher Ikwara, Atwijukiire Humphrey, Kasande Meble, Wamaani Gamukama Hannington, Emmanuel Chiebuka Jacob, Isaac Isiko   +5 more
doaj   +1 more source

A Year of Prevention in Action: Southwest PA Says No More [PDF]

, 2016
Southwest PA Says NO MORE represents a growing community of organizations and individuals who are working to end domestic and sexual violence in a 10-countyregion of southwestern Pennsylvania.

core  

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

No One Cried For Help: The Integration of Groupthink into Modern Rape Culture [PDF]

, 2014
Rape symbolizes lost innocence. Many young females increasingly endure sexual violence at the hands of multiple male assailants. Despite the common coupling of group dynamics and rapes, little evidence proposes Irving Janis’s theory of groupthink as one ...
Hermann, Jourdin
core   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Intimacy, pleasure and the men who pay for sex [PDF]

, 2008
About the repository: This book brings together chapters by academics, researchers and practitioners to analyse how crimes such as sex work, domestic violence and rape and sexual assault have risen up the Government agenda in recent years.
Earle, Sarah, Sharp, Keith
core  

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Correction: Intimate partner violence against women during pregnancy: a systematic review and meta‑analysis protocol for producing global and regional estimates

Systematic Reviews, 2023
Leah Schrubbe, Claudia García‑Moreno, Lynnmarie Sardinha, Heidi Stöckl   +3 more
doaj   +1 more source

It’s Not Just the What but the How [PDF]

, 2015
White House Task Force to Protect Students From Sexual Assault looked to Prevention Innovations Research Center to evaluate efficacy of strategies for prevention and response to sexual violence on ...
Banyard, Victoria, Demers, J. M., Edwards, Katie M., Moynihan, Mary, Potter, Sharyn J.   +4 more
core   +1 more source