Results 201 to 210 of about 93,431 (321)

A new CRISPR‐mediated Apc knockout allele leads to pyloric gland adenoma‐like gastric polyps in mice with C57BL/6;FVB/N mixed background

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The exon 16 of the mouse Apc gene was targeted with CRISPR/Cas9 system and a novel Apc knockout mouse model was generated by creating a frameshift mutation at codon 750 (ApcΔ750). The polyp number, polyp distribution and the overall survival of mice carrying the ApcΔ750 allele significantly differs between the F8‐FVB‐ApcΔ750 and F4‐B6;FVB‐ApcΔ750 mouse
Sarp Uzun   +7 more
wiley   +1 more source

Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat   +6 more
wiley   +1 more source

Exploring drivers and prevention strategies for sexual violence among adolescent girls and young women in Kicukiro, Rwanda. [PDF]

open access: yesFront Reprod Health
Kawonga WP   +6 more
europepmc   +1 more source

The ATM Kinase Inhibitor AZD0156 is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and is an Attractive Candidate for Medicinal Chemistry Optimisation Ag…

open access: yesAngewandte Chemie International Edition, Accepted Article.
New compounds targeting human malaria parasites are critical for effective malaria control and elimination. Here, we pursued the imidazoquinolinone AZD0156 (MMV1580483), a human ataxia‐telangiectasia mutated (ATM) kinase inhibitor that completed Phase I clinical trials as an anticancer agent.
John G. Woodland   +33 more
wiley   +1 more source

Community perceptions about factors influencing access to care after sexual violence in North Kivu, Democratic Republic of the Congo: a qualitative study. [PDF]

open access: yesConfl Health
Reinholdz H   +6 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy