Results 221 to 230 of about 2,105,134 (400)

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Understanding sexual violence: Perspectives from an adolescent HIV prevention study. [PDF]

J Public Health Afr
Ahmed N, Webb E, Muhumuza R, Ssemata AS, Atujuna M, Stranix-Chibanda L, Nematadzira T, Dietrich JJ, Tshabalala G, Hornschuh S, Weiss HA, Seeley J, Fox J.   +12 more
europepmc   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Sexual violence against women with disabilities: intersection between race/color and vulnerability. [PDF]

BMC Public Health
Caluaco HGF, Hino P, Fernandes FSL, Siqueira LD, Caldas JMP, Vieira EWR, Fernandes H.   +6 more
europepmc   +1 more source

Exploring the use of geographic methods to understand sexual- and gender-based violence: a scoping review

Madeleine D. Sheppard-Perkins, Tomoko McGaughey, Paul A. Peters, Francine Darroch   +3 more
openalex   +2 more sources

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

Racism in health services: a lack of care of violence against black women victims of sexual violence Racismo nos serviços de saúde: a ausência do cuidado com as mulheres negras vítimas de violência sexual [PDF]

, 2015
Alba Jean Batista Viana, Eduardo Sérgio Soares Sousa, Ednalva Maciel Neves   +2 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

An ecological model of barriers to accessing care for pregnancy resulting from sexual violence: a rapid review. [PDF]

Reprod Health
Gilliland PD, Ha SD, Phipps JE, Simmons LA.   +3 more
europepmc   +1 more source

Rape and Sexual Violence by the Burmese Army

, 2014
Chloé Pellegrini
openalex   +1 more source