Results 31 to 40 of about 90,914 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prevalence, Characteristics, and Factors Associated With Sexual Violence in Adulthood Among Brazilian MSM

American Journal of Men's Health, 2022
Most studies of sexual violence are with women, and although men who have sex with men (MSM) is the group of the men that has been most investigated for sexual violence, there are still several questions to be answered about sexual violence and sexual ...
Denis Gonçalves Ferreira, Maria Amelia Veras, Gustavo Santa Roza Saggese, Mark Drew Crosland Guimarães, Laio Magno, Ines Dourado, Raimunda Hermelinda Maia Macena, Andréa Fachel Leal, Carl Kendall, Edgar Mércham-Hamann, Ximena Pamela Díaz Bermúdez, Daniela Knauth, Ligia Regina Sansigolo Kerr   +12 more
doaj   +1 more source

Prevalence of Sexual Violence in Higher Education Institutions based on Witness Testimony

Analitika, 2023
This research aims to assess the prevalence of sexual violence in higher education as initial exploratory data based on data from witnesses or individuals who have seen or are aware of sexual violence in the campus academic community. Respondents in this
Iriani indri Hapsari, Deasyanti, Fellianti Muzdalifah   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Enhancing care for transgender and gender diverse survivors of intimate partner violence: an Ontario-wide survey examining health and social service providers’ learning needs

BMJ Open
Objectives To better understand healthcare and social/community service providers’ learning needs associated with supporting transgender and gender diverse (trans) persons who have experienced intimate partner violence (IPV).Setting An online survey was ...
Sarah Daisy Kosa, Sheila Macdonald, Robin Mason, C Emma Kelly, Janice A Du Mont, Sydney Brouillard-Coyle, Hyuna Seo   +6 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Strengthening parental safeguarding against intrafamilial child sexual abuse: Sexual assault counselors’ window into salient family dynamics and prevention

Child Protection and Practice
Background: A substantial proportion of childhood sexual abuse occurs in family settings. Intrafamilial child sexual abuse can commence at a very early age, be long lasting and can impact a child's entire early social system.
Shona L. Innes, Susan Rayment-McHugh, Harriot Beazley   +2 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Sosialisasi Pencegahan Kekerasan Seksual di Lingkungan Sekolah Menengah Atas Negeri 15 Padang

Warta Pengabdian Andalas, 2023
Schools become one of the secondary socialization agents that children get. Unfortunately, schools are a place that is prone to sexual violence. Therefore, it is necessary to socialize the prevention of sexual violence in schools so that schools become ...
Wahyu Pramono, Dwiyanti Hanandini, Nini Anggraini, Indah Sari Rahmaini   +3 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source