Results 51 to 60 of about 90,914 (259)

Psychological safety in sport: validation of the French Sport Psychological Safety Inventory (SPSI-FR)

Frontiers in Psychology
IntroductionPsychological safety is increasingly recognized as a key determinant of athletes’ wellbeing and sustainable performance, particularly in youth sport.
Véronique Boudreault, Véronique Boudreault, Juliette Maurin, Lara Pomerleau-Fontaine, Charles-Anthony Dubeau, Francelyne Jean-Baptiste, Sophie Brassard, Jacinthe Dion, Jacinthe Dion, Jacinthe Dion, Jacinthe Dion, Sylvie Parent, Sylvie Parent, Sylvie Parent, Sylvie Parent   +14 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The Name.Narrate.Navigate (NNN) Program: A Case Study of Tertiary Intervention for Justice-Involved Youth in Regional Australia

Behavioral Sciences
Name.Narrate.Navigate (NNN) is a trauma-informed program for justice-involved young people aged 12–18 years, recognising that experience and use of violence are often interconnected and may involve serious criminal behaviour, including vulnerability to ...
Tamara Blakemore, Louise Rak, Susan Rayment-McHugh, Elsie Randall, Chris Krogh, Meaghan Katrak Harris, Sally Hunt, Daniel Ebbin, Graeme Stuart, Shaun McCarthy   +9 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Child marriage practice in the eyes of evangelical church leader and elders in the Wonisho district of the Sidama region, Southern Ethiopia

Humanities & Social Sciences Communications
Despite regional government initiatives and development agency efforts, child marriage remains deeply entrenched in Ethiopia, underscoring the need for sustained intervention.
Turufat Tukura, Sibilo Gashure
doaj   +1 more source

Building knowledge to improve access to inclusive and equitable care for trans and gender-diverse survivors of sexual assault and intimate partner violence: a qualitative research protocol

BMJ Open
Introduction Intimate partner violence (IPV) and sexual assault are pervasive public health and human rights concerns that disproportionately impact trans and gender-diverse (TGD) individuals.
Alexa R Yakubovich, Janice Du Mont, Sarah Daisy Kosa, Sheila Macdonald, Danielle Toccalino, C Emma Kelly, Sav Jonsa, Adam Davies   +7 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

[Sexual violence--sexualized violence].

Psychiatria Danubina, 2006
The fusion of sexuality and violence is a major issue of concern and has become a central issue of social policy. That fusion can be observed in private circumstances as well as in society at large. Children and young people as well as women and men can fall victim to that phenomenon.
openaire   +1 more source