Results 71 to 80 of about 93,431 (321)

Chat Control or Child Protection? [PDF]

open access: yesarXiv, 2022
Ian Levy and Crispin Robinson's position paper "Thoughts on child safety on commodity platforms" is to be welcomed for extending the scope of the debate about the extent to which child safety concerns justify legal limits to online privacy. Their paper's context is the laws proposed in both the UK and the EU to give the authorities the power to ...
arxiv  

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

open access: yesAdvanced Science, EarlyView.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen   +6 more
wiley   +1 more source

Testing for personality consistency across naturally occurring behavioral contexts in sanctuary chimpanzees (Pan troglodytes)

open access: yesAmerican Journal of Primatology, Volume 85, Issue 1, January 2023., 2023
Sanctuary chimpanzees show consistency of their personality‐based behaviors across real‐life contexts and over time while displaying interindividual differences in the consistency of their personality‐based behavioral profile Abstract Personality is both a reflection of the bio‐behavioral profile of individuals and a summary of how they typically ...
Hélène Chotard   +3 more
wiley   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

open access: yesAdvanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang   +13 more
wiley   +1 more source

Viruses in sanctuary chimpanzees across Africa

open access: yesAmerican Journal of Primatology, Volume 85, Issue 1, January 2023., 2023
Abstract Infectious disease is a major concern for both wild and captive primate populations. Primate sanctuaries in Africa provide critical protection to thousands of wild‐born, orphan primates confiscated from the bushmeat and pet trades. However, uncertainty about the infectious agents these individuals potentially harbor has important implications ...
Emily Dunay   +9 more
wiley   +1 more source

Demographic Representation and Collective Storytelling in the Me Too Twitter Hashtag Activism Movement [PDF]

open access: yesarXiv, 2020
The #MeToo movement on Twitter has drawn attention to the pervasive nature of sexual harassment and violence. While #MeToo has been praised for providing support for self-disclosures of harassment or violence and shifting societal response, it has also been criticized for exemplifying how women of color have been discounted for their historical ...
arxiv  

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Elemental models of primate nursing and weaning revisited

open access: yesAmerican Journal of Biological Anthropology, Volume 180, Issue 1, Page 216-223, January 2023., 2023
Abstract Objectives Intra‐tooth patterns of trace elements barium (Ba) and strontium (Sr) have been used to infer human and nonhuman primate nursing histories, including australopithecine and Neanderthal juveniles. Here, we contrast the two elemental models in first molars (M1s) of four wild baboons and explore the assumptions that underlie each ...
Tanya M. Smith   +4 more
wiley   +1 more source

Unveiling Local Patterns of Child Pornography Consumption in France using Tor [PDF]

open access: yesarXiv, 2023
Child pornography represents a severe form of exploitation and victimization of children, leaving the victims with emotional and physical trauma. In this study, we aim to analyze local patterns of child pornography consumption across 1341 French communes in 20 metropolitan regions of France using fine-grained mobile traffic data of Tor network-related ...
arxiv  

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

open access: yesAdvanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu   +19 more
wiley   +1 more source

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