Results 81 to 90 of about 16,419,233 (281)

A contextual behavioral model of chemsex: structural equation modeling of psychological predictors of hypersexuality and drug use

Frontiers in Psychology
Background and objectiveChemsex, defined as the intentional use of psychoactive substances in sexual contexts, is increasingly prevalent among gay and bisexual men and is associated with a range of mental, physical and social implications.
Rubén Rico, Francisco Montesinos
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Chemsex and sexual risk behavior among MSM on PrEP in Stockholm, Sweden

Drug and Alcohol Dependence Reports
Background: Chemsex, typically defined as the use of specific psychoactive substances to enhance sexual experiences, has been linked to increased sexual health risks among men who have sex with men (MSM).
Rost Elin, Westergren Victor, Luksha Yauheni, Anna Mia Ekström, Lindberg Daniel   +4 more
doaj   +1 more source

Supplemental Material - Sexualized drug use and STD and HIV incidence among men who have sex with men in Amsterdam, the Netherlands

, 2023
Supplemental Material for Sexualized drug use and STD and HIV incidence among men who have sex with men in Amsterdam, the Netherlands by Carien M Blomaard, Vita W Jongen, Roel CH Achterbergh, Maarten F Schim van der Loeff and Henry JC de Vries in ...
Vita W Jongen (16041619), Roel CH Achterbergh (16041622), Henry JC de Vries (16041628), Carien M Blomaard (16041616), Maarten F Schim van der Loeff (16041625)   +4 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Patterns of drug combinations used by men who have sex with men in Brazil [PDF]

Brazilian Journal of Psychiatry
Objective: The practice of using drugs to modulate experiences is a well-documented phenomenon worldwide, particularly among men who have sex with men (MSM).
Rodrigo Nikobin, Julio Mella-Cobas, Maria Amelia Veras, Francisco Inácio Bastos, Jordi Casabona Barbarà, Valeria Stuardo Ávila, Dartiu Xavier da Silveira   +6 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Sexualized Drug Use among Gay, Bisexual, and Other Men Who Have Sex with Men: A Scoping Review of Health Risks and Nursing Implications

Fundamental and Management Nursing Journal
Introduction: Sexualized drug use (SDU), known as chemsex or slamsex, is a growing phenomenon among gay, bisexual, and men who have sex with men (GBMSM). SDU is associated with an increased risk of HIV transmission and other adverse health outcomes.
Dicky Endrian Kurniawan, Ahmad Rifai, Alfid Tri Afandi, M. Nur Khamid   +3 more
doaj   +1 more source

sj-pdf-1-std-10.1177_09564624211041456 – Supplemental Material for Sexualized drug use and specialist service experience among MSM attending urban and rural sexual health clinics in England and Scotland

, 2021
Supplemental Material, sj-pdf-1-std-10.1177_09564624211041456 for Sexualized drug use and specialist service experience among MSM attending urban and rural sexual health clinics in England and Scotland by Richard Kennedy, Jennifer Murira, Kirsty Foster ...
Lynn Chalmers (10856070), Katy Sinka (350241), Richard Kennedy (248483), Jennifer Murira (11472019), Frances Keane (11472022), Ellen Heinsbroek (2735248), Nisha Pal (11472025), Kirsty Foster (566607)   +7 more
core   +1 more source

HIV Sexual and Drug-Use Risk in Drug-Dependent Pregnant Patients in Comprehensive Drug Treatment [PDF]

International Journal of Family Medicine, 2011
This secondary analysis study investigated HIV sexual and drug-use risk in drug-dependent pregnant patients over the first month postrandomization to reinforcement-based treatment (RBT) () or usual care (UC) (). Analysis of primary outcomes had indicated that RBT participants spent significantly longer time in treatment and recovery housing than UC ...
Hendrée E. Jones, Wendee M. Wechsberg, Kevin E. O'Grady, Michelle Tuten   +3 more
openaire   +2 more sources