Results 51 to 60 of about 2,148,996 (264)

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Proportion of early treatment seeking for sexually transmitted infections and associated factors among patients attending youth friendly service in Bahir Dar City health centers, Northwest, Ethiopia

Reproductive Health
Background Sexually transmitted infection is a common public health issue of youths and is characteristically transmitted through sexual intercourse.
Getachew Zeleke, Alemtshay Mekonnen, Tigist Abuhay, Muluken Chanie Agimas   +3 more
doaj   +1 more source

Characteristic Male Urine Microbiomes Associate with Asymptomatic Sexually Transmitted Infection [PDF]

, 2010
Article discussing research on characteristic male urine microbiomes associated with asymptomatic sexually transmitted ...
Nelson, David E., Lixia Diao, Weinstock, George M., 1949-, Dong, Qunfeng, David E. Nelson, Nelson David E., Kashi V Revanna, Diao, Lixia, Baochang Fan, Weinstock, George M., J Dennis Fortenberry, David E Nelson, George M. Weinstock, Revanna Kashi V., Qunfeng Dong, Sodergren, Erica, Erica Sodergren, Fan Baochang, Fortenberry J. Dennis, Van Der Pol, Barbara, Barbara Van Der Pol, Van Der Pol Barbara, George M Weinstock, Fan, Baochang, Revanna, Kashi V., Easwaran Shraddha, Weinstock George M., Kashi V. Revanna, Fortenberry, J. Dennis, J. Dennis Fortenberry, Dong Qunfeng, Sodergren Erica, Diao Lixia, Shraddha Easwaran, Easwaran, Shraddha   +34 more
core   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Survey on Sexually Transmitted Infection Test of One Referral Laboratory in Seoul: Focused on Multiple Sexually Transmitted Diseases

Korean Journal of Clinical Laboratory Science, 2020
Currently, sexually transmitted diseases (STD) are referred to as “sexually transmitted infections" (STIs) in the sense of including asymptomatic infections. STIs have a range of interrelationships.
Dong-In Seok, Hyun Ho Sung, Chang-Eun Park   +2 more
doaj   +1 more source

Quality and equity of private sector care for sexually transmitted diseases in South Africa.

, 2002
The private sector plays a major role in the delivery of health care in South Africa. Over the past two decades, the quality and equity of such provision has been questioned internationally.
Brugha, Ruairí, Schneider, Helen, Chabikuli, Nzapfurundi, Zwi, Anthony B, Blaauw, Duane   +4 more
core   +1 more source

Violated and vulnerable: women's experiences of contracting a sexually transmitted infection from a male partner [PDF]

, 2017
Aims and objectives To explore women's stories of contracting a sexually transmitted infection from a male partner and elucidate the gendered constructs and violence experienced that made the women vulnerable to these infections.
Peters, K, Leah East, Debra Jackson, East, L, Peters, Kath, Jackson, Debra, Jackson, D, Peters, Kathleen (R11662), Kath Peters, East, Leah   +9 more
core   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

HIV phylogenetic clusters point to unmet hiv prevention, testing and treatment needs among men who have sex with men in kenya

BMC Infectious Diseases
Background The HIV epidemic in Kenya remains a significant public health concern, particularly among gay, bisexual, and other men who have sex with men (GBMSM), who continue to bear a disproportionate burden of the epidemic.
François Cholette, Lisa Lazarus, Pascal Macharia, Jeffrey Walimbwa, Samuel Kuria, Parinita Bhattacharjee, Helgar Musyoki, Mary Mugambi, Martin K. Ongaro, Kennedy Olango, Janet Musimbi, Faran Emmanuel, Shajy Isac, Michael Pickles, Marissa L. Becker, Sharmistha Mishra, Lyle R. McKinnon, James Blanchard, John Ho, Omari Henry, Rissa Fabia, Paul Sandstrom, Robert Lorway, Souradet Y. Shaw   +23 more
doaj   +1 more source