Results 61 to 70 of about 1,274,085 (313)

The effectiveness and cost-effectiveness of behavioural interventions for the prevention of sexually transmitted infections in young people aged 13-19: a systematic review and economic evaluation [PDF]

, 2010
ObjectivesTo assess the effectiveness and cost-effectiveness of schools-based skills-building behavioural interventions to encourage young people to adopt and maintain safer sexual behaviour and to prevent them from acquiring sexually transmitted ...
Price, A., Barnett-Page, Elaine, D Hartwell, Kavanagh, J., Cooper, Keith, Shepherd, Jonathan, A Clegg, E Barnett-Page, Clegg, A., Hartwell, D., Frampton, G.K., J Shepherd, GK Frampton, A Price, J Kavanagh, Picot, J, K Cooper, Jones, Jeremy, Hartwell, D, Picot, Joanna, J Jones, A Harden, Harden, A., Jones, J., Harden, Angela, Kavanagh, Josephine, Barnett-Page, E., J Picot, Clegg, Andy, Price, Alison, Frampton, G   +30 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Sexually Transmitted Infections in Adolescents [PDF]

North Carolina Medical Journal, 2013
Sexually transmitted infections (STIs) are very common in teenagers and young adults, with adolescents making up a disproportionate percentage of cases. This article reviews the epidemiology of STIs in North Carolina adolescents and summarizes current recommendations for screening, testing, and treatment.
openaire   +2 more sources

Genital ulcers and concomitant complaints in men attending a sexually transmitted infections clinic: implications for sexually transmitted infections management. [PDF]

, 2008
BACKGROUND: Although genital herpes has emerged as the most common cause of genital ulcers in Southern Africa, treatment for herpes is not available routinely in the region.
O'Farrell, Nigel, Moodley, Prashini, Pillay, Keshree, Morison, Linda, Vanmali, T, Quigley, M, Sturm, A Wim, Vanmali, Trusha, Moodley, P, Quigley, Maria, Sturm, AW, Morison, L, O'Farrell, N, Pillay, K   +13 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

A scoping review of media campaign strategies used to reach populations living with or at high risk for Hepatitis C in high income countries to inform future national campaigns in the United Kingdom

BMC Infectious Diseases, 2023
Background With the advent of direct acting antivirals, the World Health Organisation proposed eliminating Hepatitis C as a public health threat by 2030. To achieve this, countries need to diagnose, engage in care and treat their undiagnosed populations.
David Etoori, Monica Desai, Sema Mandal, William Rosenberg, Caroline A Sabin   +4 more
doaj   +1 more source

Sexually transmitted infection in the elderly [PDF]

Sexually Transmitted Infections, 1998
“Age brings changes at 70 just as at 17. But you never outgrow your need for intimate love and affection.”1 There is little medical literature concerning sexually transmitted infection in the elderly. The paucity of published information may reflect the low clinical workload this population generates within genitourinary medicine (GUM) services, but ...
R D, Cranston, R N, Thin
openaire   +2 more sources

Studying complex interactions among determinants of healthcare-seeking behaviours: self-medication for sexually transmitted infection symptoms in female sex workers.

, 2010
OBJECTIVES: To describe the frequency and determinants of self-medication for symptoms of sexually transmitted infections (STI) in a female sex worker (FSW) population.
Garnett, Geoffrey P, P. E. Campos, C. Buendia, Gomez, Gabriela B, Ward, Helen, Carcamo, Cesar P, Holmes, King K, W. L. Whittington, C. P. Carcamo, Segura, Patricia, G. B. Gomez, K. K. Holmes, P. Segura, Whittington, William L, Campos, Pablo E, Garcia, Patricia J, J. P. Hughes, Buendia, Clara, Hughes, James P, H. Ward, P. J. Garcia, G. P. Garnett   +21 more
core   +1 more source