Results 71 to 80 of about 1,274,085 (313)

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Functionally-informed fine-mapping identifies genetic variants linking increased CHD1L expression and HIV restriction in monocytes

Scientific Reports
Human Immunodeficiency Virus Type 1 (HIV) set-point viral load is a strong predictor of disease progression and transmission risk. A recent genome-wide association study in individuals of African ancestries identified a region on chromosome 1 ...
Riley H. Tough, Paul J. McLaren, The International Collaboration for the Genomics of HIV   +2 more
doaj   +1 more source

Should Mycoplasma penetrans be considered a pathogen in anal specimens from men who have sex with men?

International Journal of Infectious Diseases
Objectives: This study was performed to assess the prevalence of Mycoplasma penetrans in anal samples collected from men who have sex with men (MSM) undergoing screening for Chlamydia trachomatis and Neisseria gonorrhoeae and to identify factors ...
Audrey Tokpassi, Marie Gardette, Cécile Laurier, Cécile Bébéar, Olivia Peuchant   +4 more
doaj   +1 more source

Paired testing of sexually transmitted infections with urine pregnancy tests in incarcerated women [PDF]

, 2021
Background: In correctional facilities, sexually transmitted infections (STIs) are common, are often asymptomatic, and may lead to adverse outcomes such as infertility and increased HIV acquisition. In January 2020, testing for Neisseria gonorrhoeae (GC)
Pao, Julie, Nijhawan, Ank E., Dang, Christine M., Taherzadeh, Dena   +3 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Microbicides for the Prevention of HPV, HIV-1, and HSV-2: Sexually Transmitted Viral Infections

, 2017
Sexually transmitted diseases (STDs) can be transmitted through genital-genital, oro-genital, or anogenital contacts and remain to be a public health concern worldwide.
Roman Farooq, Umer, Muhammad, Muhammad Umer, Naveed Shahzad, Farooq, Roman, Aslam, Bilal, Bilal Aslam, Shahzad, Naveed   +7 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

The impact of the COVID-19 pandemic on Sexually Transmitted Infections surveillance data: incidence drop or artefact?

BMC Public Health, 2021
Background Before the COVID-19 pandemic, Sexually transmitted infections (STIs) were increasing in Europe, and Spain and Catalonia were not an exception.
Alexis Sentís, Albert Prats-Uribe, Evelin López-Corbeto, Marcos Montoro-Fernandez, Daniel Kwakye Nomah, Patrícia Garcia de Olalla, Lilas Mercuriali, Núria Borrell, Víctor Guadalupe-Fernández, Juliana Reyes-Urueña, Jordi Casabona, Catalan HIV and STI Surveillance Group   +11 more
doaj   +1 more source

Quality and equity of private sector care for sexually transmitted diseases in South Africa.

, 2002
The private sector plays a major role in the delivery of health care in South Africa. Over the past two decades, the quality and equity of such provision has been questioned internationally.
Brugha, Ruairí, Schneider, Helen, Chabikuli, Nzapfurundi, Zwi, Anthony B, Blaauw, Duane   +4 more
core   +1 more source