Results 61 to 70 of about 22,122 (243)

Non-local SFT tachyon and cosmology [PDF]

Journal of High Energy Physics, 2007
Cosmological scenarios built upon the generalized non-local String Field Theory and $p$-adic tachyons are examined. A general kinetic operator involving an infinite number of derivatives is studied as well as arbitrary parameter $p$. The late time dynamics of just the tachyon around the non-perturbative vacuum is shown to leave the cosmology trivial. A
openaire   +2 more sources

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Recent Advances in the Study of the Immune Escape Mechanism of SFTSV and Its Therapeutic Agents

Viruses, 2023
Sever fever with thrombocytopenia syndrome (SFTS) is a new infectious disease that has emerged in recent years and is widely distributed, highly contagious, and lethal, with a mortality rate of up to 30%, especially in people with immune system ...
Lei Chen, Tingting Chen, Ruidong Li, Yingshu Xu, Yongai Xiong   +4 more
doaj   +1 more source

Toward Knowledge‐Guided AI for Inverse Design in Manufacturing: A Perspective on Domain, Physics, and Human–AI Synergy

Advanced Intelligent Discovery, EarlyView.
This perspective highlights how knowledge‐guided artificial intelligence can address key challenges in manufacturing inverse design, including high‐dimensional search spaces, limited data, and process constraints. It focused on three complementary pillars—expert‐guided problem definition, physics‐informed machine learning, and large language model ...
Hugon Lee, Hyeonbin Moon, Junhyeong Lee, Seunghwa Ryu   +3 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Unusual Solitary Fibrous Tumors in the Central Nervous System: A Report of Two Cases

Kaohsiung Journal of Medical Sciences, 2005
Solitary fibrous tumors (SFTs) are uncommon, and most are found in the pleura. Extrapleural SFTs are rare and have been found in the lung, pericardium, mediastinum, soft tissue of any site, and upper respiratory tract. SFTs of the central nervous system (
Shih-Wen Hu, Kun-Bow Tsai, Sheau-Fang Yang, Chee-Yin Chai   +3 more
doaj   +1 more source

Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan

Emerging Infectious Diseases, 2021
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease caused by SFTS virus (SFTSV). We report 7 cases of spontaneous fatal SFTS in felines.
Yusuke Sakai, Yuko Kuwabara, Keita Ishijima, Saya Kagimoto, Serina Mura, Kango Tatemoto, Ryusei Kuwata, Kenzo Yonemitsu, Shohei Minami, Yudai Kuroda, Kenji Baba, Masaru Okuda, Hiroshi Shimoda, Masashi Sakurai, Masahiro Morimoto, Ken Maeda   +15 more
doaj   +1 more source

SFT based cosmological models [PDF]

Journal of Physics: Conference Series, 2010
We consider the appearance of multiple scalar fields in SFT inspired non-local models with a single scalar field at late times. In this regime all the scalar fields are free. This system minimally coupled to gravity is mainly analyzed in this note. We build one exact solution to the equations of motion. We consider an exactly solvable model which obeys
openaire   +2 more sources

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

Factors Associated With the Spatial Distribution of Severe Fever With Thrombocytopenia Syndrome in Zhejiang Province, China: Risk Analysis Based on Maximum Entropy

JMIR Public Health and Surveillance
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was first identified in mainland China in 2009 and has been reported in Zhejiang Province, China, since 2011.
Mingyong Tao, Ying Liu, Feng Ling, Jiangping Ren, Rong Zhang, Xuguang Shi, Song Guo, Jianmin Jiang, Jimin Sun   +8 more
doaj   +1 more source