Results 11 to 20 of about 54,917 (299)
The Role of SGLT2 Inhibitors in Atherosclerosis: A Narrative Mini-Review [PDF]
Frontiers in Pharmacology, 2021 Objective: Sodium glucose cotransporter 2 inhibitors (SGLT2-is) are antidiabetic drugs that improve glycemic control by limiting urinary glucose reuptake in the proximal tubule.
Aurélie Pahud de Mortanges +7 more
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Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides. [PDF]
PLoS ONE, 2014 Aminoglycoside antibiotics, like gentamicin, continue to be clinically essential worldwide to treat life-threatening bacterial infections. Yet, the ototoxic and nephrotoxic side-effects of these drugs remain serious complications.
Meiyan Jiang +5 more
doaj +2 more sources
SGLT2 inhibition and kidney protection [PDF]
Clinical Science, 2018 Type 2 diabetes mellitus (T2DM) is a growing public health concern worldwide. Numerous drug classes are available for treatment, however, their efficacy with regard to diabetes-induced renal and cardiovascular (CV) complications remains limited.
Nespoux, Josselin, Vallon, Volker
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Evolving Clinical Features of Diabetic Ketoacidosis: The Impact of SGLT2 Inhibitors [PDF]
PharmaceuticalsBackground/Objectives: The antidiabetic effect of SGLT2 inhibitors (SGLT2-is) is based on their ability to increase glucose excretion through urine by inhibiting the kidney-resident SGLT2 protein.
Selin Genc +7 more
doaj +2 more sources
Research Progress of SGLT2 Inhibitors in Cancer Treatment [PDF]
Drug Design, Development and TherapyXiaoyong Miao,1,* Jianing Zhang,2,* Weiyan Huang,2,* Yifei Wang,1 Aixia Jin,1 Jianping Cao,1 Zhenzhen Zhao3 1Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, People’s Republic of China; 2Student Brigade,
Miao X +6 more
doaj +1 more source
Pflügers Archiv - European Journal of Physiology, 2020 Abstract Glycolysis plays a central role in tumor metabolism and growth, and this is reflected in a high rate of glucose uptake. It is commonly assumed that the upregulation of the facilitated glucose transporter GLUT1 meets the tumor’s demand for sugar.
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, 2014 SGLT2 inhibition in diabetic ...
Muralikrishna Gangadharan komala (595016)
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SGLT2 Inhibitors and Their Antiarrhythmic Properties [PDF]
International Journal of Molecular Sciences, 2022 Sodium-glucose cotransporter 2 (SGLT2) inhibitors are gaining ground as standard therapy for heart failure with a class-I recommendation in the recently updated heart failure guidelines from the European Society of Cardiology. Different gliflozins have shown impressive beneficial effects in patients with and without diabetes mellitus type 2, especially
Ewald Kolesnik +6 more
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Outcomes in diabetic patients treated with SGLT2-Inhibitors with acute myocardial infarction undergoing PCI: The SGLT2-I AMI PROTECT Registry [PDF]
, 2023 To investigate in-hospital and long-term prognosis in T2DM patients presenting with acute myocardial infarction (AMI) treated with SGLT2-I versus other oral anti-diabetic agents (non-SGLT2-I users)
Santulli, Gaetano +49 more
core +1 more source
An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]
, 2012 Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Manju Sharma +4 more
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