Results 21 to 30 of about 54,917 (299)

Sodium-glucose co-transporter 2 (SGLT2) inhibitors: a growing class of anti-diabetic agents [PDF]

, 2014
Although several treatment options are available to reduce hyperglycemia, only about half of individuals with diagnosed diabetes mellitus (DM) achieve recommended glycemic targets.
Eva M Vivian
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Effects of Sodium-Glucose Transporter 2 Inhibitors (SGLT2-I) in Patients With Ischemic Heart Disease (IHD) Treated by Coronary Artery Bypass Grafting via MiECC: Inflammatory Burden, and Clinical Outcomes at 5 Years of Follow-Up

Frontiers in Pharmacology, 2021
Introduction: Minimally invasive extracorporeal circulation (MiECC) reduced inflammatory burden, leading to best clinical outcomes in patients treated with coronary artery bypass grafting (CABG).
Celestino Sardu, Celestino Sardu, Massimo Massetti, Massimo Massetti, Nicola Testa, Luigi Di Martino, Gaetano Castellano, Fabrizio Turriziani, Ferdinando Carlo Sasso, Michele Torella, Marisa De Feo, Gaetano Santulli, Gaetano Santulli, Gaetano Santulli, Giuseppe Paolisso, Giuseppe Paolisso, Raffaele Marfella, Raffaele Marfella   +17 more
doaj   +1 more source

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption

, 2023
The sodium–glucose cotransporter 2 (SGLT2) mainly carries out glucose reabsorption in the kidney. Familial renal glycosuria, which is a mutation of SGLT2, is known to excrete glucose in the urine, but blood glucose levels are almost normal ...
Tadashi Hase, Kyoko Taguchi, Shinichi Meguro, Keiko Unno, Yoshiichi Takagi, Yoriyuki Nakamura, Unno, Keiko, Hase, Tadashi, Taguchi, Kyoko, Nakamura, Yoriyuki, Meguro, Shinichi, Takagi, Yoshiichi   +11 more
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Sodium-glucose co-transporter-2 inhibitors reduce the risk of new-onset stroke in patients with type 2 diabetes: A population-based cohort study

Frontiers in Cardiovascular Medicine, 2022
BackgroundEpidemiological evidence suggests the association of diabetes with an increased risk of stroke. Clinical studies have investigated the effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on new-onset stroke (NOS), but the results are ...
Tsung-Kun Lin, Tsung-Kun Lin, Yong-Hsin Chen, Yong-Hsin Chen, Jing-Yang Huang, Jing-Yang Huang, Pei-Lun Liao, Mei-Chun Chen, Lung-Fa Pan, Lung-Fa Pan, Gwo-Ping Jong   +10 more
doaj   +1 more source

Effect of sodium-glucose cotransporter 2 inhibitor in patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus: a propensity score-matched analysis of real-world data

Therapeutic Advances in Endocrinology and Metabolism, 2021
Background: Although sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) improve not only glycemic control but also liver inflammation and fatty changes in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), its ...
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Shigeru Mikami, Hiroki Ono, Tadamichi Kawano, Yuji Yoshida, Tomohide Tanabe, Tomomi Okubo, Korenobu Hayama, Ai Nakagawa-Iwashita, Norio Itokawa, Chisa Kondo, Keiko Kaneko, Naoya Emoto, Mototsugu Nagao, Kyoko Inagaki, Izumi Fukuda, Hitoshi Sugihara, Katsuhiko Iwakiri   +19 more
doaj   +1 more source

SGLT2 Inhibitors: Physiology and Pharmacology [PDF]

Kidney360, 2021
SGLTs are sodium glucose transporters found on the luminal membrane of the proximal tubule, where they reabsorb some 180 g (1 mol) of glucose from the glomerular filtrate each day. The natural glucoside phlorizin completely blocks glucose reabsorption. Oral SGLT2 inhibitors are rapidly absorbed into the blood stream, where theyremain in the circulation
openaire   +2 more sources

Short Communication: Immunohistochemical study of sodium-dependent glucose co-transporters in ostriches kidneys

Agraarteadus, 2020
Out of the two families of glucose transporters identified, the sodium-dependent glucose co-transporters contribute to renal glucose reabsorption. Due to the lack of knowledges of the localization of SGLTs in bird's kidneys, the present study aimed to ...
Piret Hussar, Ilmārs Dūrītis, Florina Popovska-Percinic, Tõnu Järveots   +3 more
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SGLT2: A PERSPECTIVE ON PATHOPHYSIOLOGY AND IMPACT OF SGLT2 INHIBITION ON RENAL FUNCTION

International Journal of Advanced Research, 2023
In individuals with diabetes, kidney size and glomerular filtration rate (GFR) tend to increase, and elevated GFR is a risk factor for diabetic kidney disease. Hyperfiltration occurs when high glucose levels in the glomerular filtrate causes increased reabsorption of glucose and sodium by the sodium-glucose cotransporters SGLT2 and SGLT1 in the ...
Manish Hathial, Chandrakiran Hathial, Jayant Makwana, Anita George, Priyanka Bhat, Bhagyashree Yadav, Ganesh Nandgiri   +6 more
openaire   +1 more source

SGLT2 figures_Supplem_Figshare.pdf

, 2022
 Supplemental data for the manuscript  "SGLT2 inhibition effect on salt-induced hypertension, RAAS, and sodium transport in Dahl SS rats"
Olha Kravtsova (12369751)
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Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets

Сахарный диабет, 2015
In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1 ...
Ivan Nikolaevich Tyurenkov, Denis Vladimirovich Kurkin, Elena Vladimirovna Volotova, Dmitriy Alexandrovich Bakulin, Elena Michailovna Lomkina   +4 more
doaj   +1 more source