Results 131 to 140 of about 38,769 (305)

Urinary Collagen Peptides Predict Mortality

PROTEOMICS, EarlyView.
ABSTRACT Organ fibrosis caused by the presence of excessive extracellular matrix (ECM) is related to mortality. Urinary peptide signatures were reported to be predictive of death in SARS‐CoV‐2 and chronic kidney disease. Such signatures were composed for 68% of collagen fragments.
Maria Frantzi, Felix Keller, Agnieszka Latosinska, Joachim Beige, Alexandre Mebazaa, Anaïs Caillard, Dewei An, Paul Perco, Joost P. Schanstra, Lorenzo Catanese, Ralph Wendt, Harald Rupprecht, Jan A. Staessen, Antonia Vlahou, Harald Mischak, Justyna Siwy   +15 more
wiley   +1 more source

The Impact of Different Antidiabetic Drugs on Fracture Risk in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials With a Focus on SGLT2 Inhibitors

American Journal of Medicine Open
SGLT2 inhibitors are a new class of antidiabetic drugs that have shown cardiovascular benefits in patients with type 2 diabetes mellitus (T2DM) and cardiovascular disease. However, their effects on fracture risk are unclear and may depend on the type and
Bushra Admani, MBBS, Fizza Zehra Raza, MBBS, Fatima Siddiqui, MBBS, Muhammad Talal Ashraf, MBBS, Muhammad Khuzzaim Khan, MBBS, Ifra Habib, MBBS, Ayesha Usman, MBBS, Bareeha Mansoor, MBBS, Zaira Nadeem, MBBS, Rana Jahanzeb Ghaffer, MBBS, Muhammad Riyyan, MBBS, Sawaira Sajid, MBBS, Muhammad Hassan Ali Chania, MBBS, Mahnoor Saleem, MBBS, Saad Javaid, MBBS, Nikhil Duseja, MBBS, Hussam Al Hennawi, MD, Sunita Lakhani, MD   +17 more
doaj   +1 more source

Nephrological perspectives on the underutilization of SGLT2is in heart failure and chronic kidney disease

ESC Heart Failure, Volume 12, Issue 2, Page 1490-1491, April 2025.
Özant Helvacı, Ömer Faruk Akçay, Emre Yaşar, Ülver Derici, Galip Güz   +4 more
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Time-varying cost-effectiveness analysis of sodium-glucose cotransporter-2 inhibitors in Chinese patients with heart failure and reduced ejection fraction: A microsimulation of the real-world population

Frontiers in Pharmacology
ObjectiveSodium-glucose cotransporter-2 (SGLT2) inhibitors showed time-varying effects in heart failure and reduced ejection fraction (HFrEF), but corresponding cost-effectiveness in different timeframes remained poorly understood.
Xinyu Zou, Xingchen He, Qingyang Shi, Qingyang Shi, Si Wang, Nan Li, Yiling Zhou, Yiling Zhou, Ming Hu, Li Luo, Yiwen Shen, Ye Zhu, Chim C. Lang, Zhiming Zhu, Haoming Tian, Sheyu Li   +15 more
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

SGLT2 Inhibitors in Liver Patients [PDF]

Clinical Gastroenterology and Hepatology, 2020
John Chen Hsiang, Vincent Wai-Sun Wong
openaire   +2 more sources

Use of Glucagon‐Like Peptide 1 Receptor Agonists and the Associated Risk of Hospitalisation in Bipolar Disorder, From a Nationwide Cohort, 2009–2024

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Diabetes, obesity and bipolar disorder often co‐occur and may have shared pathophysiology. Glucagon‐like peptide 1 receptor agonists (GLP‐1RA) treat diabetes and obesity but their impact on bipolar disorder is unknown. In this era of stagnated pharmacotherapy, we examined psychiatric hospitalisation and absence from work due to ...
Heidi Taipale, Mark Taylor, Markku Lähteenvuo, Ellenor Mittendorfer‐Rutz, Antti Tanskanen, Jari Tiihonen   +5 more
wiley   +1 more source

Computational Discovery of Novel SGLT2 Inhibitors from Eight Selected Medicine Food Homology Herbs Using a Multi-Stage Virtual Screening Pipeline

Pharmaceuticals
Background/Objectives: Sodium-glucose co-transporter 2 (SGLT2) inhibitors are essential antidiabetic medications. However, their side effects warrant careful consideration.
Zeyu Chen, Kaiqi Tan, Yi Shi, Muchong Liu, Lang Yi, Tongxi Chen, Yunlong Bai   +6 more
doaj   +1 more source

Ketoacidosis and SGLT2 Inhibitors: A Narrative Review

Metabolites
An acute metabolic complication of diabetes mellitus, especially type 1, is diabetic ketoacidosis (DKA), which is due to an increase in blood ketone concentrations. Sodium/glucose co-transporter-2 inhibitor (SGLT2-i) drugs have been associated with the occurrence of a particular type of DKA defined as euglycemic (euDKA), characterized by glycemic ...
Carmela Morace, Giuseppe Lorello, Federica Bellone, Cristina Quartarone, Domenica Ruggeri, Annalisa Giandalia, Giuseppe Mandraffino, Letteria Minutoli, Giovanni Squadrito, Giuseppina T. Russo, Herbert Ryan Marini   +10 more
openaire   +4 more sources