Results 31 to 40 of about 2,682 (215)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Tolerability of SGLT2 inhibitors in patients with Fabry disease: An observational study

American Heart Journal Plus
Cardiac involvement of Fabry disease (FD) includes heart failure (HF) treated according to general guideline recommendations. The retrospective study investigates HF medication in FD focusing on sodium glucose cotransporter 2 (SGLT2) inhibitors.
Isabel Mattig, Berit Zirkelbach, Carina Bonnekoh, Karl Stangl, Gerhard Hindricks, Fabian Knebel, Sima Canaan-Kühl, Sebastian Spethmann   +7 more
doaj   +1 more source

Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids

Advanced Science, EarlyView.
Mechanochemically generated organocalcium species display unusual chemoselectivity toward carboxylates, enabling direct ketone synthesis without overaddition. Ball milling activates commercial calcium metal under ambient, solvent‐minimized conditions, providing a broad substrate scope, high functional‐group tolerance, and a practical one‐step ...
Mengyao Pei, Zekun Yang, Xueyan Yang, Yufang Yang, Yangyang Shen, Jiemin Wang, Peile Ma, Zezhu Li, Xiaoliang Zheng, Xiaofeng Wei   +9 more
wiley   +1 more source

Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Scientific Reports, 2017
Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Type 2 diabetes mellitus (T2DM). However, the clinical usage of carbasugar SGLT2 inhibitors has been underexplored, due to the lengthy ...
Wai-Lung Ng, Ho-Chuen Li, Kit-Man Lau, Anthony K. N. Chan, Clara Bik-San Lau, Tony K. M. Shing   +5 more
doaj   +1 more source

SGLT2 inhibitors in cardiovascular medicine [PDF]

European Heart Journal - Cardiovascular Pharmacotherapy, 2021
Varzideh, Fahimeh, Kansakar, Urna, Santulli, Gaetano   +2 more
openaire   +3 more sources

Chances and risks of SGLT2 inhibitors [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2011
Type II diabetes mellitus (T2DM) is characterised by relative insulin deficiency caused by resistance of important target organs like liver and skeletal muscle towards insulin. During the course of the disease, pancreatic insulin production becomes decreased, and absolute insulin deficiency results (Kahn 2003).
openaire   +2 more sources

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Review on SGLT2 Inhibitors

Asian Journal of Pharmaceutical Research and Development, 2023
The pharmaceutical industry employs a variety of analytical techniques to test the quality, concentration, and composition of medicines in biological fluids. This review work to provide the most existing analytical methods for the analysis of SGLT2 inhibitors (Empagliflozin, Dapagliflozin, Canagliflozin) in active pharmaceutical ingredients, biological
Pravin Dighe, Namrata Kale
openaire   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

The effects of sodium-glucose cotransporter-2 inhibitors in chemotherapy-induced cardiotoxicity and mortality in patients with cancer: a systematic review and meta-analysis

Cardio-Oncology
Background The effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on reducing cardiovascular events in different subgroups of diabetic patients are under investigation. The current systematic review and meta-analysis investigated the effects of
Tara Reshadmanesh, Reza Mohebi, Amir Hossein Behnoush, Azadeh Reshadmanesh, Amirmohammad Khalaji, Mitra Norouzi, Elmira Javanmardi, Reza Pishdad, S. Reza Jafarzadeh, Elina Ghondaghsaz, Sandra Chaparro   +10 more
doaj   +1 more source