Results 31 to 40 of about 34,392 (132)

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd, Gerd Geisslinger, Brandes, Ralf P., Brandes, Ralf, Michael J Fischer, Fleming, Ingrid, Scholich, Klaus, Woolf Clifford J, Ralf P Brandes, Clifford J Woolf, Fleming Ingrid, Reeh, Peter Werner, Brenneis Christian, Fischer, Michael, Coste Ovidiu, Coste, Ovidiu, Brandes Ralf P, Kai Altenrath, Reeh Peter W, Christian Brenneis, Scholich Klaus, Sisignano, Marco, Reeh, Peter W., Altenrath Kai, Ingrid Fleming, Peter W Reeh, Woolf, Clifford J., Angioni Carlo, Geisslinger Gerd, Angioni, Carlo Federico, Klaus Scholich, Brenneis, Christian, Ovidiu Coste, Carlo Angioni, Sisignano Marco, Marco Sisignano, Fischer, Michael J., Fischer Michael J, Altenrath, Kai, Angioni, Carlo   +39 more
core   +3 more sources

Deciphering the modular structure of phage depolymerase: a dual-action strategy for biofilm degradation and targeted Pseudomonas aeruginosa binding

Microbiology Spectrum
Pseudomonas aeruginosa is a critical ESKAPE pathogen that can form strong biofilms, which protect it from antibiotics and the host’s immune system. Enzymes from bacteriophages, called depolymerases, are often found in tail fiber proteins and provide a ...
Yu-Chuan Tsai, Ling-Chun Lin
doaj   +1 more source

Identification and Characterization of a New Alkaline SGNH Hydrolase from a Thermophilic Bacterium Bacillus sp. K91

Journal of Microbiology and Biotechnology, 2016
est19 is a gene from Bacillus sp. K91 that encodes a new esterase. A comparison of the amino acid sequence showed that Est19 has typical Ser-Gly-Asn-His (SGNH) family motifs and could be grouped into the SGNH hydrolase family. The Est19 protein was functionally cloned, and expressed and purified from Escherichia coli BL21(DE3).
Tingting, Yu, Junmei, Ding, Qingxia, Zheng, Nanyu, Han, Jialin, Yu, Yunjuan, Yang, Junjun, Li, Yuelin, Mu, Qian, Wu, Zunxi, Huang   +9 more
openaire   +2 more sources

Infection mechanisms of Rhizoctonia cerealis in wheat

iMeta, Volume 5, Issue 5, October 2026.
We discover that R. cerealis (Rc) is a primary pathogen causing sharp eyespot of wheat after 335 distinct isolates were isolated from 1683 SE‐diseased wheat plants across China over 7 years using a single hyphal tip isolation method. We then generated high‐quality reference genomes via de novo sequencing of five representative Rc isolates and ...
Yan Ren, Ti Liu, Heying Zhao, Qirun Qian, Lufei Cui, Zhipeng Sun, Wenkai Yang, Peng Guo, Sisheng Wang, Lingran Zhang, Congwei Sun, Aolin Jia, Ning Zhang, Feng Chen   +13 more
wiley   +1 more source

Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. [PDF]

, 2011
Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses.
Olejnik, Kamil, Kujawa, Martyna, Modzelan, Marta, Anielska-Mazur, Anna, Kraszewska, Elzbieta, Lipko, Agata, Bucholc, Maria, Augustyn, Agnieszka   +7 more
core   +2 more sources

Dissecting multi‐rust resistance in wheat through genome‐wide association study, haplotype analysis, and marker validation

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Wheat is a major global staple food affected by three diseases: leaf rust (LR), stem rust (SR), and stripe rust (YR), all of which can cause substantial yield losses. Identifying genotypes with broad‐spectrum resistance to diverse pathotypes of all three rusts remains a major challenge.
Thamaraikannan Sivakumar, Divya Sharma, V. K. Vikas, Neeraj Budhlakoti, O. P. Gangwar, Pramod Prasad, Ankita Mohapatra, Sathishkumar R, Deepak Singh Bisht, Priyanka Jain, Ritu Sharma, Bonipas Antony John, Reyazul Rouf Mir, Farkhandah Jan, Dwijesh C. Mishra, Satinder Kaur, Amit Kumar Singh, G. P. Singh, Sundeep Kumar   +18 more
wiley   +1 more source

Cloning and expression of SGNH-hydrolase of Streptomyces coelicolor in heterologous host [PDF]

, 2009
Bakterijske SGNH-hidrolaze su značajna grupa enzima koja još uvijek nije dobro istražena, ni strukturalno ni biokemijski. Izvanstanična lipaza iz obitelji SGNH-hidrolaza iz bakterije Streptomyces coelicolor soja A3(2) (Q93J06, SCO7513) je djelomično ...
Marić, Marija
core  

Pseudotetraivprolide aus Pseudomonas entomophila liefern Einblicke in die Biosynthese von Detoxin/Rimosamid‐ähnlichen Anti‐Antibiotika

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Pseudotetraivprolid ist ein neuer Akteur unter den Detoxin/Rimosamid‐ähnlichen Naturstoffen. Die Biosynthese erfordert FabD aus dem Primärstoffwechsel und einen PipDFG‐Komplex für die Acetylierung im letzten Schritt – wodurch schließlich die anti‐antibiotische Wirkung entsteht.
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source

Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics

Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.
Pseudotetraivprolide is a new player among the Detoxin/Rimosamide‐like natural products! Its biosynthesis requires FabD from primary metabolism and a PipDFG complex for final‐step acetylation – unlocking its anti‐antibotic activity. Abstract Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis ...
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source

EnzyKR: A Chirality-Aware Deep Learning Model for Predicting the Outcomes of the Hydrolase-Catalyzed Kinetic Resolution [PDF]

, 2023
Hydrolase-catalyzed kinetic resolution is a well-established biocatalytic process. However, the computational tools that predict the favorable enzyme scaffolds for separating racemic substrate mixture are underdeveloped.
Xinchun, Ran, Zhongyue J., Yang, Qianzhen, Shao, Yaoyukun, Jiang   +3 more
core   +2 more sources