Results 51 to 60 of about 6,290 (168)

Dual versus monotherapy with bronchodilators in GOLD group B COPD patients according to baseline FEV1 level: a patient-level pooled analysis of phase-3 randomized clinical trials

Respiratory Research, 2021
Background Which patients should receive dual therapy as initial treatment for chronic obstructive pulmonary disease (COPD) is only loosely defined. We evaluated if a lower forced expiratory volume in 1 s (FEV1) identifies a population more likely to ...
Jieun Kang, Jae Seung Lee, Sei Won Lee, Jung Bok Lee, Yeon-Mok Oh   +4 more
doaj   +1 more source

Contrasting Global and Patient‐Specific Regression Models via a Neural Network Representation

Biometrical Journal, Volume 68, Issue 2, April 2026.
ABSTRACT When developing clinical prediction models, it can be challenging to balance between global models that are valid for all patients and personalized models tailored to individuals or potentially unknown subgroups. To aid such decisions, we propose a diagnostic tool for contrasting global regression models and patient‐specific (local) regression
Max Behrens, Daiana Stolz, Eleni Papakonstantinou, Janis M. Nolde, Gabriele Bellerino, Angelika Rohde, Moritz Hess, Harald Binder   +7 more
wiley   +1 more source

Assessing health status in COPD. A head-to-head comparison between the COPD assessment test (CAT) and the clinical COPD questionnaire (CCQ)

BMC Pulmonary Medicine, 2012
Background Health status provides valuable information, complementary to spirometry and improvement of health status has become an important treatment goal in COPD management.
Tsiligianni Ioanna G, van der Molen Thys, Moraitaki Despoina, Lopez Ilaine, Kocks Janwillem WH, Karagiannis Konstantinos, Siafakas Nikolaos, Tzanakis Nikolaos   +7 more
doaj   +1 more source

Destroyed Lung Syndrome—A Devastating and Neglected Consequence of Pulmonary Tuberculosis: Case Series From a Low‐Resource Setting in Ghana

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Post‐pulmonary TB destroyed lung syndrome. ABSTRACT Tuberculous destroyed lung syndrome is a devastating and often neglected sequela of pulmonary tuberculosis. It has significant adverse effects on the quality of life of affected patients. This case series aims to raise awareness among clinicians and to emphasize the need for multifaceted preventive ...
Prosper Adjei, Kingsley Owusu Manu, Samuel Kyeremeh Adjei, Theophilus Nyamekye Yeboah, Bridget Maame Kweenuwa Ansah, Daniel Kwabena Asare, Fatimata Musah, Safura Alhassan   +7 more
wiley   +1 more source

Mapping EQ-5D-5L Score From SGRQ in Patients with Asthma and/or COPD in NOVELTY

Pragmatic and Observational Research
The St George's Respiratory Questionnaire (SGRQ) measures health status in obstructive airways disease. Starkie et al proposed an algorithm for mapping the SGRQ to EQ-5D-5L, a preference-based utility measure, in chronic obstructive pulmonary disease (COPD) (Value Health 2011;14:354-60); only SGRQ total score, its squared value, and sex were included ...
Dan Jackson, Anna Quinton, Fanni Zhang, Hana Müllerová, Christer Janson, Mohsen Sadatsafavi   +5 more
openaire   +5 more sources

Is the St. George’s Respiratory Questionnaire an Appropriate Measure of Symptom Severity and Activity Limitations for Clinical Trials in COPD? Analysis of Pooled Data from Five Randomized Clinical Trials

International Journal of COPD, 2020
Angely Loubert,1 Antoine Regnault,1 Juliette Meunier,1 Florian S Gutzwiller,2 Stéphane A Regnier2 1Modus Outcomes, Lyon, France; 2Novartis Pharma AG, Basel, SwitzerlandCorrespondence: Angely LoubertModus Outcomes, 61 Cours De La Liberté ...
Loubert A, Regnault A, Meunier J, Gutzwiller FS, Regnier SA   +4 more
doaj  

Relationship between FEV₁ change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review

Respiratory Research, 2011
Background Interactions between spirometry and patient-reported outcomes in COPD are not well understood. This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with ...
Cerulli Annamaria, Jones Paul W, Bourbeau Jean, Westwood Marie, Capkun-Niggli Gorana, Worthy Gill   +5 more
doaj   +1 more source

Pulmonary Obstruction and Age, Not Activity, Associate With Muscle Oxidative Impairment in Smokers With and Without COPD

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Low muscle oxidative capacity is an extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) with unclear aetiology. We sought to characterize locomotor muscle oxidative capacity in never smokers and ever smokers with and without COPD and determine clinical and behavioural features associated with low muscle ...
Alessandra Adami, Fenghai Duan, Robert A. Calmelat, Zeyu Chen, Richard Casaburi, Harry B. Rossiter   +5 more
wiley   +1 more source

Health status in COPD cannot be measured by the St George's Respiratory Questionnaire alone: an evaluation of the underlying concepts of this questionnaire

Respiratory Research, 2010
Background Improving patients' health status is one of the major goals in COPD treatment. Questionnaires could facilitate the guidance of patient-tailored disease management by exploring which aspects of health status are problematic, and which aspects ...
Dekhuijzen PN Richard, Molema Johan, Peters Jeannette B, Daudey Leonie, Prins Judith B, Heijdra Yvonne F, Vercoulen Jan H   +6 more
doaj   +1 more source

Identification of Clinically Distinct Clusters in Patients With Severe COPD Using Circulating Blood Cell Population Parameters

Respirology, Volume 31, Issue 2, Page 141-151, February 2026.
This study investigated whether blood cell population data, in addition to cell counts, can identify clinically relevant COPD subgroups. Four distinct inflammatory profiles were identified with distinct clinical characteristics. Cell population data have the potential to provide additional insights beyond inflammatory cell counts and improve patient ...
Pauline J. M. Kuks, Jorine E. Hartman, Else A. M. D. ter Haar, L. Joost van Pelt, Dirk‐Jan Slebos, Maarten van den Berge, Simon D. Pouwels   +6 more
wiley   +1 more source