Results 181 to 190 of about 416,610 (233)

Acute myocardial infarction induces sex-specific, time-dependent remodeling of the gut microbiome and intestinal immune compartment in retired breeder C57BL/6N mice. [PDF]

Front Microbiomes
Pal E, Omidi Arjenaki N, Lu Y, Xia J, Chalifour L.   +4 more
europepmc   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Integrative analysis of 16S rRNA sequencing and network pharmacology suggests protective effects of Sihuang Zhili Granules against APEC O78 challenge through gut homeostasis-related changes. [PDF]

Front Vet Sci
Guo Z, Wang X, Cai D, Guo Z, Cheng P, Zeng J, Liu H, Liu Y.   +7 more
europepmc   +1 more source

Universal Strategy for Phase‐Selective Synthesis of Monolayer TMDs via Colloidal Chemistry

Advanced Materials, EarlyView.
ABSTRACT Colloidal synthesis of monolayer transition metal dichalcogenides (TMDs) remains challenging regarding uniform size, thickness, and crystalline phase. While significant progress has been made in phase engineering, a unified chemical strategy for on‐demand selection of both 2H and 1T′ phases across multiple TMD systems within a single chemical ...
Hoon Ju Lee, Weiguang Yang, Dae Young Park, Mrinal Kanti Kabiraz, Benoit Mahler, Hyeon Suk Shin   +5 more
wiley   +1 more source

KDM4D enhances radiosensitivity in esophageal squamous cell carcinoma through the SRBD1/RPL11/c-Myc/WIP1/CHK1 axis. [PDF]

Am J Transl Res
Gao Z, Han X, Yuan S.
europepmc   +1 more source

Origin of Dark Current Robustness in Photomultiplication Organic Photodetectors Enabled by Ionic Conjugated Electron‐Blocking Layers

Advanced Materials, EarlyView.
Ionic conjugated polyelectrolyte electron‐blocking layers enable photomultiplication organic photodetectors with dark current robustness up to −10 V and external quantum efficiencies exceeding 3000%. Fowler–Nordheim tunneling, interfacial dipole, trap density of states, and noise analyses reveal how ionic conjugated polyelectrolytes suppress electron ...
Yelim Kang, Min Hun Jee, Shuai Zhang, Sang Heon Lee, Jung Min Ha, Xingchao Zhao, Xiaoling Ma, Huiseong Shin, Changhwan Shin, Soonyong Lee, Fujun Zhang, Jae Won Shim, Han Young Woo   +12 more
wiley   +1 more source

Theranostic Nanoparticles Based on a Silicon Dioxide Core, a Mercapto Spacer, a Cardioprotector, and a Fluorescent Dye. [PDF]

Int J Mol Sci
Korolev DV, Shulmeyster GA, Baybakova MA, Anufriev IE, Galagudza MM.   +4 more
europepmc   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

IL-17RA Promotes Cigarette Smoke-Induced Alveolar Epithelial Cell Pyroptosis in COPD via Dual Activation of the NLRP3/Caspase1/GSDMD and NF-κB/GSDME Pathways. [PDF]

J Inflamm Res
An X, Gu Y, Zhou J, Liu Y, Yu S, Zhang L, Ouyang Y.   +6 more
europepmc   +1 more source