Results 111 to 120 of about 37,099 (235)

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

open access: yesCell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang   +14 more
wiley   +1 more source

Tunnelling Nanotube‐Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy

open access: yesCell Proliferation, EarlyView.
This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang   +16 more
wiley   +1 more source

Can a lizard ride on a housefly?: Navigating uncertainty and moral life in an Accra Zongo, Ghana

open access: yesEthos, EarlyView.
Abstract How can uncertainty become a resource for ethical life rather than a threat to it? Focusing on a Zongo community in Accra, Ghana—also known as a “traveler's camp” or “stranger's quarters”—this article examines how people use a creative form of communication called the practice of folding to sustain relationships shaped by conditions of ...
Emily A. Williamson
wiley   +1 more source

Use of the Multidimensional Haemophilia Pain Questionnaire (MHPQ) in Patients With Severe Haemophilia A Treated With Emicizumab: A Pilot Cross‐Sectional, Single‐Centre Study

open access: yesHaemophilia, EarlyView.
ABSTRACT Background Despite effective bleed prevention with Emicizumab, pain remains a relevant clinical burden in adults with severe haemophilia A (sHA). A multidimensional assessment is needed to better characterize contemporary haemophilia‐related pain.
Ilenia Lorenza Calcaterra   +7 more
wiley   +1 more source

THE NAITŌ HYPOSTASIS: NAITŌ KONAN (1866–1934) AND THE JAPANESE IMPERIALIST LEGACY IN THE HISTORIOGRAPHY OF MIDDLE‐PERIOD CHINA (800–1400 CE)

open access: yesHistory and Theory, EarlyView.
ABSTRACT In 1955, Hisayuki Miyakawa published an article that sought to introduce American and European scholars to the work of the Japanese Sinologist Naitō Konan (1866–1934). Miyakawa drew particular attention to what he called the “Naitō hypothesis”—that is, Naitō’s argument that China became modern during the Song dynasty (960–1279).
CHRISTIAN DE PEE
wiley   +1 more source

Miners' Reward Elasticity and Stability of Competing Proof‐of‐Work Cryptocurrencies

open access: yesInternational Economic Review, EarlyView.
ABSTRACT Proof‐of‐Work cryptocurrencies employ miners to sustain the system through algorithmic reward adjustments. We develop a stochastic model of the multicurrency mining and identify conditions for stable transaction speeds. Bitcoin's algorithm requires hash supply elasticity <$<$1 for stability, while ASERT remains stable for any elasticity and ...
Kohei Kawaguchi   +2 more
wiley   +1 more source

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