Results 41 to 50 of about 21,838,242 (247)

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Electron Transfer‐Tailored D‐Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning‐Empowered Intelligent Biosensing

Advanced Science, EarlyView.
This study pioneers a rational nanozyme design strategy guided by electron transfer mechanisms while advancing biosensing paradigms through interpretable machine learning‐enhanced signal intelligence. By transforming biosensors from passive transducers to active diagnostic systems, this work establishes a versatile framework for addressing global ...
Yuechun Li, Chenxin Ji, Zhaowen Cui, Jianxing Feng, Liang Zhang, Sha Liu, Wentao Zhang, Yanwei Ji, Yizhong Shen, Jianlong Wang   +9 more
wiley   +1 more source

Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis

Advanced Science, EarlyView.
This study develops a diagnostic platform for early detection of esophageal squamous cell carcinoma (ESCC) by integrating a barcode immunoassay biochip with machine learning. The biochip captures and analyzes small extracellular vesicle proteins from serum samples, identifying nine biomarkers linked to ESCC.
Xue Zhang, Yibin Jia, Zhikai Li, Yunhong Zhang, Chao Wang, Yanbo Liang, Jiaoyan Qiu, Mingyuan Sun, Xiaoshuang Chen, Miao Huang, Yu Zhang, Jianbo Wang, Hong Liu, Chuanbin Mao, Lin Han   +14 more
wiley   +1 more source

Hyperspectral Fluorescence Imaging with a New Polarity‐Ultrasensitive Fluorescent Probe

Advanced Science, EarlyView.
Based on the critical role of the π‐spacer in determining wavelength sensitivity to microenvironmental polarity, a new fluorescent probe, Lipi‐PS is rationally developed, which exhibits the highest polarity‐sensitivity so far. Its integration with hyperspectral fluorescence imaging enables multiscale polarity mapping across cells, tissues, and ...
Ri Zhou, Hao Sha, Shengjie Fu, Guannan Liu, Jinbei Wei, Chenguang Wang, Shangguo Hou, Geyu Lu   +7 more
wiley   +1 more source

King and Cochrane: The technological treadmill and racial inequity in US agriculture

Applied Economic Perspectives and Policy, EarlyView.
Abstract Between 1920 and 1969, the number of Black farmers in the US decreased from 14% of all operators to 4%. Using Martin Luther King Jr.'s critique of agricultural policy and Willard Cochrane's theory of the technological treadmill, we explore how racial discrimination was linked to policies that led to structural change in US agriculture.
Jared Hutchins, Jacopo De Marinis
wiley   +1 more source

How do both firm‐level resources and country‐level competitiveness shape the relationship between alliance portfolio diversity and radical innovation? A comparison between the food and other manufacturing industries

Agribusiness, EarlyView.
Abstract This study examines how European food companies can operationally leverage the value created by strategic alliances into commercially viable products. More importantly, it emphasizes that the effects of alliance portfolio diversity (APD) on radical innovation performance can be achieved not only directly, but also via moderating roles, that is,
María Ancín, Ferdaous Zouaghi, Mercedes Sánchez   +2 more
wiley   +1 more source

Are all meats substitutes? A basket‐and‐expenditure‐based approach

Agribusiness, EarlyView.
Abstract This study examines the relationship among animal‐based meat and plant‐based meat alternatives (PBMAs) using a basket‐and‐expenditure‐based choice experiment. In particular, we examine whether animal‐based meat products are substitutes or complements with PBMAs.
Clinton L. Neill, Logan L. Britton
wiley   +1 more source

A Universal Doping Strategy for Boosting Luminescence Efficiency of Blue‐Emitting Hybrid Zn Halides as Ultrastable and Underwater Scintillators

Aggregate, EarlyView.
A Pb2+‐doping method is demonstrated to be a universal strategy to realize near‐unity photoluminescence quantum yield and high water‐resistance stability for a family of blue‐emitting zero‐dimensional Zn2+‐based halides through increasing the exciton binding energy and carrier density.
Zhi‐Wei Chen, Na Lin, Xin‐Yue Zhang, Yu‐Sha Yan, Li Xiao, Yi‐Fan Wu, Cheng‐Yang Yue, Dongpeng Yan, Xiao‐Wu Lei   +8 more
wiley   +1 more source

Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas

Advanced Intelligent Systems, EarlyView.
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang, Dingsi Xiang, Shengli Mi, Jiajun Huang   +3 more
wiley   +1 more source

Centimeter‐Scale Magneto‐Reconfigurable Parallel Robots: A Grassmann Line Geometry Synthesis Framework for Multitask Adaptation Using Magneto‐Connected Part Library

Advanced Intelligent Systems, EarlyView.
A low‐cost, Lego‐like magneto‐connected part library is proposed, capable of rapidly assembling, disassembling, and reassembling compact, centimeter‐scale parallel robots with various motion types, balancing structural rigidity and reconfiguration agility.
Yunong Li, Bin Zhu, Wenchao Yue, Zhiwei Fang, Xiao Xiao, Hongliang Ren   +5 more
wiley   +1 more source