Results 111 to 120 of about 368,858 (384)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The topographic development and areal parametric characterization of a stratified surface polished by mass finishing [PDF]
, 2015 Mass finishing is amongst the most widely used finishing processes in modern manufacturing, in applications from deburring to edge radiusing and polishing. Processing objectives are varied, ranging from the cosmetic to the functionally critical. One such
Walton, Karl +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2017 Focusing on the theory of shadowing of approximate trajectories (pseudotrajectories) of dynamical systems, this book surveys recent progress in establishing relations between shadowing and such basic notions from the classical theory of structural ...
Pilyugin, Sergei Yu +3 more
core +1 more source
Statistical peer-to-peer channel models for outdoor urban environments at 2GHz and 5GHz [PDF]
, 2004 The paper provides a new statistical propagation model that addresses a number of gaps in the area of peer-to-peer radio channel modelling in an urban microcellular environment.
Nix, AR, Wang, Z, Tameh, EK
core +1 more source
Finite-Expansivity and N-Shadowing
, 2021 We prove that every finite-expansive homeomorphism with the shadowing property has a kind of stability. This stability will be good enough to imply both the shadowing property and the denseness of periodic points in the chain recurrent set.
Morales C.A. +3 more
core +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2005 Com o objetivo de verificar as flutuações de temperatura e umidade do solo em resposta à cobertura vegetal, realizou-se um experimento com sete diferentes situações de cobertura do solo, constituídas por solo sem cobertura, presença de vegetação ...
Milson L. de Oliveira +3 more
doaj +1 more source