Results 101 to 110 of about 2,297,694 (287)

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

open access: yes
Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

open access: yesAdvanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu   +5 more
wiley   +1 more source

Research on calculation method of compressive bearing capacity of pre-bored grouted planted pile in soft soil area

open access: yesYantu gongcheng xuebao
As a kind of green and environmental-friendly embedded pile, pre-bored grouted planted (PGP) pile has been successfully applied in the eastern coastal soft soil area of China in recent years.
GONG Xiaonan 1 , LUO Ziang 1, ZHOU Jiajin 2, ZHANG Rihong 3
doaj   +1 more source

Studies on the shaft coupling (1st Report) [PDF]

open access: yes, 2013
The shaft coupling connecting the drive shaft and the driven shaft, is a generic name of machine elements that transmit rotation and power. To match perfectly straight two axes is generally impossible.
396   +9 more
core  

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

open access: yesAdvanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo   +10 more
wiley   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li   +21 more
wiley   +1 more source

Seinäteippauksen suunnittelu Jame-Shaft Oy:lle [PDF]

open access: yes, 2019
Opinnäytetyön tavoitteena oli suunnitella seinäteippaus Jame-Shaft Oy:lle. Työn tarkoituksena oli luoda layout seinäteippaukselle, joka tulisi yrityksen kokoustiloihin.
Toivonen, Reetta
core  

High‐Power Hybrid Nanogenerator With Multi‐Degree‐of‐Freedom Mechanical Coupling for Harvesting Water Wave Energy

open access: yesAdvanced Science, EarlyView.
A high‐power hybrid nanogenerator (HP‐HNG) with multi‐degree‐of‐freedom mechanical coupling is reported, integrating multi‐directional wave energy for output to achieve 1 + 1 > 2 energy harvesting. The HP‐HNG achieves a peak output power of 0.764 W, corresponding to a peak power density of 127.303 W m−3. At a wave frequency of 1 Hz, the HP‐HNG delivers
Shuai Ding   +9 more
wiley   +1 more source

Shaft Resistance of Driven Piles in Overconsolidated Cohesionless Soils [PDF]

open access: yes, 2018
Piles are structural members that transfer the applied load of superstructures to deep supportive layers of soil or bedrock. Besides controlling the settlement of structures, piles provide sufficient capacity that other foundations cannot provide or ...
Alharthi, Yasir Mohammed
core   +1 more source

Moisture Migration and Variation in Pile Shaft Resistance During Hydration-Heat-Induced Thawing–Refreezing Around Cast-in-Place Piles in Permafrost

open access: yesInfrastructures
The shaft resistance of cast-in-place piles in permafrost regions is commonly estimated using the initial moisture content and frozen-soil strength parameters obtained during site investigation.
Zhilong Zhang   +3 more
doaj   +1 more source

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