Results 181 to 190 of about 47,367 (336)

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Simultaneous online monitoring of viscosity and oxygen transfer rate in shake flask cultures. [PDF]

J Biol Eng
Hanke R, Sieben M, Finger M, Schnoor K, Jeßberger S, Weyand J, de la Fuente LC, Mann M, Azizan A, Kosfeld U, Büchs J.   +10 more
europepmc   +1 more source

Shake flask methodology for assessing the influence of the maximum oxygen transfer capacity on 2,3-butanediol production. [PDF]

Microb Cell Fact, 2019
Heyman B, Lamm R, Tulke H, Regestein L, Büchs J.   +4 more
europepmc   +1 more source

Development of a semi-defined medium for high cell density cultivation of Escherichia coli in shake flask culture system

, 2015
Wenfa Ng, Yen‐Peng Ting
openalex   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Adjusting Aspergillus niger pellet diameter, population heterogeneity, and core architecture during shake flask cultivation. [PDF]

Biotechnol Biofuels Bioprod
Engelbert K, Deffur C, Cairns TC, Zhang F, Kheirkhah T, Winter H, Junne S, Neubauer P, Briesen H, Meyer V.   +9 more
europepmc   +1 more source

Solubility of refractory metals and alloys in potassium and in lithium [PDF]

Solubility of refractory metals and alloys in liquid potassium and ...
Eichelberger, R. L., Johnson, B. G., Mc Kisson, R. L.   +2 more
core   +1 more source

Detecting errors and understanding optimization strategies in scale up process of Green Fluorescent Protein using E. coli JM109 strain: A comparative study of shake flask and batch fermentation approaches [PDF]

Goshen David Miteu
openalex   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source