Results 51 to 60 of about 311,957 (305)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Seismic qualification of directional valve [PDF]
, 2001 Seismic qualification tests on pneumatically operated directional valve were carried out in the shake table facility in Structural Integrity Division. Determination of the fundamental frequency for directional valve was carried out through exploratory ...
Brahma, KK
core
Dizhen xuebao, 2023 对振动台在大行程移动过程中导轨不平顺引起的倾斜效应进行了理论分析，选择0.1 Hz及以下频点开展振动台导轨不平顺引起的台面倾斜对测试结果影响的定量化分析。结果表明，振动台面在移动过程中的不确定倾斜对地震计水平分量灵敏度的影响大于对垂直分量灵敏度的影响。采用高精度水平仪获取水平振动台在不同行程下的运动轨迹起伏变化，并基于倾斜效应的影响机制，用Labview语言实现补偿系统，在地震计的振动测试中对测试结果进行动态补偿。测试结果表明，经过动态补偿，导轨不平顺不再对灵敏度校准结果存在明显制约 ...
Jiemei Ma, Xiaoyong Fan, Wen He
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Development of a fidelity structural model based on a shake table test for an innovative seismic resisting system [PDF]
, 2014 The research project is to produce a fidelity three-dimensional (3D) structural model based on a shake table test, which is used to demonstrate performances of an innovative seismic resisting system for reducing damages to building structures under ...
Fleischman, R., Zhang, D.
core
, 2020 This file is a Persian written article demonstrating a geotechnical shaking table test in 1g.
openaire +1 more source
Shaking table tests on shallow foundations [PDF]
WIT Transactions on The Built Environment, Vol 93, 2007 In this paper the results of shaking table tests on shallow foundations, using dry Hostun RF sand, are presented. These tests were performed in a six-degree of freedom seismic simulator formed by 3 m long square table, able to move 10 t mass with up to 1-g accelerations.
J. Estaire, V. Cuéllar
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles. [PDF]
, 2017 Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma.
Alderete, Benjamin +7 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source