Results 131 to 140 of about 1,418,325 (264)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Identification and comparison of RNA structures in 5'- and 3'-terminal genomic regions across four coronavirus genera by SHAPE analysis. [PDF]

Virol J
Hsu HW, Hsu PC, Teng Y, Wang M, Hsieh FC, Yang CC, Wu HY.   +6 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Shape analysis of the amygdala, hippocampus and thalamus in former American football players. [PDF]

Brain Commun
John O, Wickham A, Jung LB, Mirmajlesi AS, Stearns J, Breedlove K, Kim N, Daneshvar DH, Billah T, Pasternak O, Chamaria A, Coleman MJ, Tripodis Y, Adler CH, Bernick C, Balcer LJ, Rushmore RJ, Alosco ML, Koerte IK, Lin AP, Cummings JL, Reiman EM, Stern RA, Shenton ME, Arciniega H, Bouix S, DIAGNOSE CTE Research Project .   +26 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Development and Performance Assessment of Single- and Double-Layer TbAG:Ce and YAG:Ce Composite Scintillators on GAGG:Ce Substrates for Optimized α-γ Discrimination and Pulse-Shape Analysis. [PDF]

Materials (Basel)
Bachiri A, Syntfeld-Każuch A, Gorbenko V, Witkiewicz-Lukaszek S, Zorenko T, Syrotych Y, Adamowski L, Swiderski L, Stasiv V, Zhydachevskyy Y, Zorenko Y.   +10 more
europepmc   +1 more source

Statistical shape analysis of maxillary palatal morphology in patients with palatally displaced canines. [PDF]

BMC Med Imaging, 2023
Sobhani F, Miresmaeili A, Mahjub H, Farhadian M.   +3 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Principal Component Analysis Applied to Digital Pulse Shape Analysis for Isotope Discrimination. [PDF]

Sensors (Basel), 2023
Guerrero-Morejón K, Hinojo-Montero JM, Muñoz-Chavero F, Flores-Garrido JL, Gómez-Galán JA, González-Carvajal R.   +5 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source