Results 141 to 150 of about 1,418,325 (264)

Three-dimensional magnetic resonance imaging-based registration techniques and statistical shape analysis for knee osteoarthritis. [PDF]

Sci Rep
Nagawa K, Hara Y, Kakemoto S, Shiratori T, Kaizu A, Koyama M, Inoue K, Sugita N, Kozawa E.   +8 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes. [PDF]

Osteoarthr Cartil Open
Lau SH, Chan LC, Jiang T, Zhang J, Meng X, Wang W, Chan PK, Cai J, Li P, Wen C.   +9 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characterizing Mandibular Morphology in Robin Sequence-A 3D Statistical Shape Analysis. [PDF]

J Craniofac Surg
El Ghoul K, O' Sullivan E, Guntaka PK, van Heesch GG, Joosten KFM, Pullens B, Khonsari RH, Resnick CM, van de Lande LS, Wolvius EB.   +9 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Clarifying species identity in Aphanopus using wavelet-based otolith shape analysis. [PDF]

PLoS One
Vasconcelos J, Martinez J, Guerra-Marrero A, Otero-Ferrer J, Jurado-Ruzafa A, Sousa R, Hernández-González C, Freitas M, Tuset VM.   +8 more
europepmc   +1 more source

Shape analysis of sand particles based on Fourier descriptors. [PDF]

Environ Sci Pollut Res Int, 2023
Yan T, Liu Y, Wei D, Sun X, Liu Q.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

3D multiscale shape analysis of nuclei and in vivo elastic stress sensors allows force inference. [PDF]

Biophys J
Jurado A, Isensee J, Hofemeier A, Krüger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T.   +7 more
europepmc   +1 more source